The Primary Immunodeficiency: Historical and Advancement Perspective

The Primary Immunodeficiency: Historical and Advancement Perspective

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Primary Immunodeficiency Disorders: A Historic and Scientific Perspective provides a complete historical context that is crucial for students and researchers concerned with primary immunodeficiency. When researchers have a poor understanding of the way we arrived where we are in research, they can miss important points about a disease, or miss out on how to approach new diseases. This historical knowledge of research can assist greatly by showing how it was done in the past, demonstrating the successes and failures, so that it can be done better in the future. This book provides an understanding of the process going from clinical problem to lab and back to the clinic, based on historical experiences. Its chapters proceed from the discovery of the T and B cell lineages through the first BMT for immunodeficiency disorder; lab investigation and gene therapy for PID; the discovery of the gene for AT and its function; understanding cytokine defects; and many other stops along the way.
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Product details

  • Hardback | 376 pages
  • 200.66 x 238.76 x 30.48mm | 1,088.62g
  • Academic Press Inc
  • San Diego, United States
  • English
  • Approx. 100 illustrations
  • 0124071791
  • 9780124071797
  • 1,771,453

Table of contents

Foreword Introduction 1. Immunity: From Serendipitous Observations To Science-Based Speciality 2. The Discovery Of The T And B Cell Compartments 3. Evolution Of The Definition Of Primary Immunodeficiencies 4. From Immunodeficiency To Autoimmunity 5. Immunological Tests - From The Microscope To Whole Genome Analysis 6. Primary Immunodeficiency In The Developing Countries 7. From A Sad Family History To A Worldwide Recognition 8. Finally Found: The Ataxia-Telangiectasia Gene and Its Function 9. Wiskott-Aldrich Syndrome: From A Fatal Hematologic Disorder To A Curable Immunodeficiency 10.Neutropenia - More Genetic Defects Than Ever Expected 11.B Cell Defects - From X Linked To Autosomal Recessive Agammaglobulinemia 12.The Discovery Of The Familial Hemophagocytosis Syndromes 13.Chronic Granulomatous Disease - From A Fatal Disease To A Curable One 14.Severe Combined Immunodeficiency - From Discovery To Newborn Screening 15.Cytokine Defects - How They Cause Severe Combined Immunodeficiency 16.The Hyper IgM Syndromes - A Long List Of Genes And Years Of Discovery 17.Unraveling The Complement System and Its Mechanism Of Action 18.The DiGeorge Syndrome: A Serendipitous Discovery 19.The Many Faces Of The Hyper IgE Syndrome 20.ADA Deficiency - The First Described Genetic Defect Causing PID 21.The Leukocyte Adhesion Deficiency Story 22.How Common Variable Immune Deficiency Has Changed Over Six Decades 23.From Subcutaneous To Intravenous Immunoglobulin And Back 24.History of Hematopoietic Stem Cell Transplantation 25.David's Story 26.How Primary Immunodeficiencies Have Made Gene Therapy A Reality
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