The Practice of Medicinal Chemistry

The Practice of Medicinal Chemistry

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Description

The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough� treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development.
Includes updated and expanded material on systems biology, chemogenomics,�computer-aided drug design, and other important recent advances in the fieldIncorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to�illustrate the global nature of medicinal chemistry and drug development researchAn image bank is available for instructors at www.textbooks.elsevier.com
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Product details

  • Electronic book text | 902 pages
  • 216 x 276mm
  • Academic Press Inc
  • San Diego, United States
  • English
  • Revised
  • 4th Revised edition
  • Approx. 175 illustrations (175 in full color)
  • 012417213X
  • 9780124172135

Table of contents

Section 1 - General Aspects of Medicinal Chemistry

Section 2 - Lead Compound Discovery Strategies

Section 3 - Primary Exploration of Structure-Activity Relationships

Section 4 - Substituents and Functions: Qualitative and Quantitative Aspects of Structure-Activity Relationships

Section 5 - Spatial Organization, Receptor Mapping and Molecular Modeling

Section 6 - Chemical Modifications Influencing the Pharmacokinetic Properties

Section 7 - Pharmaceutical and Chemical Means to Solubility and Formulation Problems
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Review quote

"The third edition of this book, useful to seasoned medicinal chemists as well as to chemists entering the academic or industrial laboratories, provides a hands-on overview of the drug discovery process. This edition differs from the previous two editions by having been updated to reflect developments in the past 5 years, and it includes 11 new chapters.I found this book to be unique, well organized, and overall a useful addition to the medicinal chemistry literature. Having favorably reviewed the first edition, I still highly recommend this third edition to all chemists who are involved in the drug discovery process."- John L. Neumeyer, Harvard Medical School, in JOURNAL OF MEDICINAL CHEMISTRY from the American Chemical Society
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