Practical Protein Crystallography

Practical Protein Crystallography

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Description

Designed for easy use by both new and experienced protein crystallographers, this book is for anyone interested in solving protein structures by the method of crystallography. It contains many examples of actual experiments and data, including electron density maps. Computer methods are also presented, including computer code examples. The book contains information on area detectors, synchrotron radiation techniques, and computer methods, and features the XtalView software system.
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Product details

  • Hardback | 386 pages
  • 149.86 x 231.14 x 22.86mm | 680.39g
  • Academic Press Inc
  • San Diego, United States
  • English
  • index, appendices
  • 0124860508
  • 9780124860506

Table of contents

Laboratory Techniques: Preparing Protein Samples. Protein Crystal Growth. Crystal Storage and Handling. Crystal Soaking. Anaerobic Crystals. Data Collection Techniques: Preparing Crystals for Data Collection. Optical Alignment. X-Ray Sources. Preliminary Characterization. Heavy Atom Derivative Scanning with Film. Overall Data Collection Strategy. Overview of Older Film Techniques. Four-Circle Diffractometer Data Collection. Area Detector Data Collection. Image Plate Data Collection. Synchrotron Radiation Light Sources. Data Reduction. Computational Techniques. Terminology. Basic Computer Techniques. Data Reduction and Statistical Analysis. The Patterson Synthesis. Fourier Techniques. Isomorphous Replacement Phasing. Molecular Replacement. Non-Crystallographic Symmetry. Density Modification. Refinement of Coordinates. Fitting of Maps. Analysis of Coordinates. Protein Crystallography Cookbook. Multiple Isomorphous Replacement. Mutant Studies. Substrate-Analog Example. Molecular Replacement.
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