Practical Pharmacology for the Use of Students of Medicine

Practical Pharmacology for the Use of Students of Medicine

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This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1920 edition. Excerpt: ... of the group of drugs act upon the heart in precisely the same way in all vertebrates. They slow the beat both by their action on the vagal mechanism and by their direct action on cardiac muscle and they increase the activity of each beat so that the output of blood per beat is increased. Numerous other drugs are employed for their action on the heart. Alcohol has an important reflex action from the mouth and stomach and after absorption affords a supply of energy from which the heart can draw. The action of sugar is probably of the same nature. Camphor has been largely advocated as a cardiac stimulant though clinical evidence of its value is not conclusive. Exp. 5. Perfuse a frog's heart with chloral hydrate as in Exp. 3, until the beat is very slow and feeble. Now inject some o-1 /0 camphor dissolved in Ringer's solution. It will be noticed that the beat returns again and becomes considerably stronger though it does not attain its former condition. Camphor has a direct stimulant action on cardiac muscle and antagonises depressant poisons. If a heart be stopped beating by arecoline, camphor will again start a feeble beat, not by antagonising the arecoline as atropine does, but by a direct stimulant action on the cardiac muscle. The nutrition of the heart is dependent upon an efficient flow of blood through the coronary vessels and so long as a suitable fluid is perfused through these vessels the heart continues to beat., Instead of blood it has been found that oxygenated Ringer's solution can be substituted and the heart in a suitable experiment beats well for many hours. In these experiments then, all that is required is to insert a cannula into the aorta of a freshly killed rabbit and perfuse the coronaries at a temperature of...show more

Product details

  • Paperback | 32 pages
  • 189 x 246 x 2mm | 77g
  • Rarebooksclub.com
  • United States
  • English
  • black & white illustrations
  • 1236885112
  • 9781236885111