Platelets

Platelets

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Description

Platelets - winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine - is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource.
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Product details

  • Hardback | 1398 pages
  • 220 x 282 x 60mm | 3,719.44g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 3rd edition
  • Approximately 350 full-color illustrations; Illustrations, unspecified
  • 0123878373
  • 9780123878373
  • 947,229

Table of contents

Foreword A Brief History of Ideas About Platelets in Health and Disease / Barry S. Coller

Part One: Platelet Biology 1. The Evolution of Mammalian Platelets / Jack Levin 2. Megakaryocyte Development and Platelet Formation / Joseph E. Italiano Jr. 3. The regulation of platelet life span / Benjamin T. Kile 4. Platelet Genomics / Willem Ouwehand, Paul F. Bray 5. Platelet MicroRNAs / Patrick Provost 6. The Platelet Proteome / Andrew S. Weyrich 7. Platelet Structure / James G. White 8. The Platelet Cytoskeleton / John H. Hartwig 9. Platelet Receptors / Kenneth J. Clemetson 10. The GPIb-IX-V Complex / Michael C. Berndt 11. GPVI and CLEC-2 / Steve P. Watson, Alice Y. Pollitt, Craig E. Hughes 12. Integrin AlphaIIb Beta3 / Edward F. Plow 13. Protease-activated Receptors / Athan Kuliopulos, Ping Zhang, Lidija Covic 14. The Platelet P2 Receptors / Marco Cattaneo 15. PECAM-1 / Peter J. Newman, Debra Newman 16. Interactions Between Platelets, Leukocytes and the Endothelium / Susan S. Smyth 17. Inhibition of Platelet Function by the Endothelium / Jane E. Freedman 18. Platelet Secretion / Robert Flaumenhaft 19. Signal Transduction During Platelet Plug Formation / Lawrence F. Brass 20. Platelet Thrombus Formation in Flowing Blood / Zaverio M. Ruggeri 21. Interactions Between Platelets and the Coagulation System / Paula B. Tracy 22. Platelet-Derived Microparticles / Rienk Nieuwland 23. The Role of Platelets in Fibrinolysis / Nicola J. Mutch 24. The Role of Platelets in Angiogenesis / Giannoula Lakka Klement, Ela Shai, David Varon 25. Platelet Function in the Newborn / Sara J. Israels

Part Two: Tests of Platelet Function 26. Clinical Tests of Platelet Function / Paul Harrison 27. Platelet Counting / Paul Harrison 28. Platelet Aggregation / Catherine Pauline Hayward, Karen A. Moffat 29. Flow Cytometry / Alan D. Michelson 30. Monitoring of Antiplatelet Therapy / Paul A. Gurbel, Udaya S. Tantry 31. Real Time In Vivo Imaging of Platelets During Thrombus Formation / Bruce Furie, Barbara Furie

Part Three: The Role of Platelets in Disease 32. Atherothrombosis and Coronary Artery Disease / Meinrad Gawaz 33. Central Nervous System Ischemia / Gregory J. del Zoppo 34. Peripheral Vascular Disease / Michael Sobel 35. Diabetes Mellitus / Giovanni Davi 36. Inflammation / Guy Zimmerman 37. Antimicrobial Host Defense / Michael R. Yeaman, Arnold Bayer 38. Tumor Growth and Metastasis / Jerry Ware

Part Four: Disorders of Platelet Number and Function 39. The Clinical Approach to Disorders of Platelet Number and Function / Alan D. Michelson 40. Immune Thrombocytopenia (ITP) / James B. Bussel, Bethan Psaila 41. Drug-induced Thrombocytopenia / Richard H. Aster 42. Heparin-induced Thrombocytopenia / Andreas Greinacher, Theodore Warkentin, Beng H. Chong 43. Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome / Han-Mou Tsai 44. Thrombocytopenia in Pregnancy / Keith R. McCrae 45. Thrombocytopenia in the Newborn / Irene A.G. Roberts 46. Alloimmune Thrombocytopenia / Cecile Kaplan, Heyu Ni, John Freedman 47. Inherited Thrombocytopenias / Mortimer Poncz, Michele P. Lambert and Ravichandran Mohan 48. Pseudothrombocytopenia / Nicola Bizzaro 49. Thrombocytosis and Essential Thrombocythemia / Ayalew Tefferi 50. Congenital Disorders of Platelet Function / Marco Cattaneo 51. Acquired Disorders of Platelet Function / A. Koneti Rao 52. Cardiopulmonary Bypass / Brian Richard Smith, Henry M. Rinder, Christine S. Rinder

Part Five: Antiplatelet Therapy 53. Aspirin / Carlo Patrono 54. ADP Receptor Antagonists / Marco Cattaneo 55. AlphaIIb Beta3 (GPIIb-IIIa) Antagonists / Anthony A. Bavry 56. Dipyridamole / Wolfgang G. Eisert 57. Cilostazol / Yasuo Ikeda, Toshiki Sudo 58. Novel Antiplatelet Therapies / Deepak L. Bhatt

Part Six: Therapy to Increase Platelet Numbers and/or Function 59. Thrombopoietin Mimetics / David J. Kuter 60. Desmopressin / Pier Mannuccio Mannucci 61. Factor VIIa / Man-Chiu Poon 62. Platelet Transfusion Medicine / Peter L. Perrotta, Jeremy Parsons, Henry M. Rinder, Edward L. Snyder 63. Making Platelets Ex Vivo / Mortimer Poncz, Spencer Sullivan, Michele P. Lambert 64. Gene Therapy for Platelet Disorders / David A. Wilcox
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Review Text

" Platelets fills an important niche on the bookshelf of any academic hematologist. The user-friendly online access to the figures contained in the textbook will be especially useful for teaching purposes.this encyclopedia of the platelet contains critical information for physicians, educators, students, and research scientists."-- HematologyTimes.com, January 29, 2014

Reviews of the Third Edition:

"Comprehensive and definitive, this third-edition reference integrates platelet biology, pathophysiology, and clinical medicine. Sixty-four chapters address biology, function, disease, disorders of platelet number or function, antiplatelet therapy, and therapy to increase numbers and/or function." --Reference and Research Book News, August 2013

"I've been reading various chapters for the past few days and have been marveling at the sheer depth and breadth. No other textbook or other reference source is comparable.You must have this book if your practice or interest even superficially touches on platelets."-- Doody.com, June 21, 2013

" Platelets is the definitive current source of state- of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine."-- Doody.com, April 24, 2013

"One might well question the value of a doorstopper-sized textbook in this era of instant Internet access to all variety of even the most arcane information. A notable exception, however, is the third edition of Michelson's Platelets . The surprising complexity of these anucleate cells and their diverse and ever enlarging roles in physiology and disease has attracted a large cadre of interdisciplinary researchers focused on various aspects of these roles. Having at ready hand a readable, authoritative, comprehensive and beautifully illustrated and cross-referenced volume makes for easy access to important information required by these researchers - both established senior investigators and their students."-- Thomas P Stossel, MD, American Cancer Society Professor of Medicine Harvard Medical School Director, Translational Medicine Unit and center for Medical Innovation Senior Physician, Hematology Division Brigham & Women's Hospital, Boston, MA, USA

Reviews of the SECOND EDITION "...the book is a clearly written, concise, and comprehensive discussion of platelets and their disorders that will be useful to anyone whose professional activity involves these important little cells." -Journal of the American Medical Association "This is a fantastic resource for anyone who treats patients with platelets disorders or is engaged in platelet or megakaryocyte-based research." - BRITISH JOURNAL OF HAEMATOLOGY

"This is the second edition of a comprehensive book on everything you could ever possibly want to know about platelets...The purpose is to provide a comprehensive, definitive, and authoritative book on platelets. These are worthy objectives, well met in this updated edition...This book would interest anyone wanting to learn about platelets: physicians at all stages of training or practice, clinical laboratory scientists at any stage of training or practice, and basic scientists interested in learning about clinical aspects of platelets...This is the book I'll use whenever I have to answer any type of platelet question. If you field platelet questions, you should get this book, too." - Valerie L. Ng, PhD, MD, Alameda County Medical Center/Highland Hospital, FOR DOODY'S (4 Stars)

Reviews of the FIRST EDITION " landmark.a useful, comprehensive reference" - New England Journal of Medicine (2003) "belongs on the bookshelf of every clinician who assesses patients with platelet disorders" - The Lancet (2003) "arguably the most complete compendium available on the subject that was once regarded as merely 'blood dust'." - British Journal of Haematology (2003) "a single-handed compilation of authoritative material" - Transfusion (2003) "a modern encyclopedia...stands out as the most compreh " Platelets fills an important niche on the bookshelf of any academic hematologist. The user-friendly online access to the figures contained in the textbook will be especially useful for teaching purposes.this encyclopedia of the platelet contains critical information for physicians, educators, students, and research scientists."-- HematologyTimes.com, January 29, 2014

Reviews of the Third Edition:

"Comprehensive and definitive, this third-edition reference integrates platelet biology, pathophysiology, and clinical medicine. Sixty-four chapters address biology, function, disease, disorders of platelet number or function, antiplatelet therapy, and therapy to increase numbers and/or function." --Reference and Research Book News, August 2013

"I've been reading various chapters for the past few days and have been marveling at the sheer depth and breadth. No other textbook or other reference source is comparable.You must have this book if your practice or interest even superficially touches on platelets."-- Doody.com, June 21, 2013

" Platelets is the definitive current source of state- of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine."-- Doody.com, April 24, 2013

"One might well question the value of a doorstopper-sized textbook in this era of instant Internet access to all variety of even the most arcane information. A notable exception, however, is the third edition of Michelson's Platelets . The surprising complexity of these anucleate cells and their diverse and ever enlarging roles in physiology and disease has attracted a large cadre of interdisciplinary researchers focused on various aspects of these roles. Having at ready hand a readable, authoritative, comprehensive and beautifully illustrated and cross-referenced volume makes for easy access to important information required by these researchers - both established senior investigators and their students."-- Thomas P Stossel, MD, American Cancer Society Professor of Medicine Harvard Medical School Director, Translational Medicine Unit and center for Medical Innovation Senior Physician, Hematology Division Brigham & Women's Hospital, Boston, MA, USA

Reviews of the SECOND EDITION "...the book is a clearly written, concise, and comprehensive discussion of platelets and their disorders that will be useful to anyone whose professional activity involves these important little cells." -Journal of the American Medical Association "This is a fantastic resource for anyone who treats patients with platelets disorders or is engaged in platelet or megakaryocyte-based research." - BRITISH JOURNAL OF HAEMATOLOGY

"This is the second edition of a comprehensive book on everything you could ever possibly want to know about platelets...The purpose is to provide a comprehensive, definitive, and authoritative book on platelets. These are worthy objectives, well met in this updated edition...This book would interest anyone wanting to learn about platelets: physicians at all stages of training or practice, clinical laboratory scientists at any stage of training or practice, and basic scientists interested in learning about clinical aspects of platelets...This is the book I'll use whenever I have to answer any type of platelet question. If you field platelet questions, you should get this book, too." - Valerie L. Ng, PhD, MD, Alameda County Medical Center/Highland Hospital, FOR DOODY'S (4 Stars)

Reviews of the FIRST EDITION " landmark.a useful, comprehensive reference" - New England Journal of Medicine (2003) "belongs on the bookshelf of every clinician who assesses patients with platelet disorders" - The Lancet (2003) "arguably the most complete compendium available on the subject that was once regarded as merely 'blood dust'." - British Journal of Haematology (2003) "a single-handed compilation of authoritative material" - Transfusion (2003) "a modern encyclopedia...stands out as the most compreh
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Review quote

Review of the Third Edition:

"One might well question the value of a doorstopper-sized textbook in this era of instant Internet access to all variety of even the most arcane information. A notable exception, however, is the third edition of Michelson's Platelets. The surprising complexity of these anucleate cells and their diverse and ever enlarging roles in physiology and disease has attracted a large cadre of interdisciplinary researchers focused on various aspects of these roles. Having at ready hand a readable, authoritative, comprehensive and beautifully illustrated and cross-referenced volume makes for easy access to important information required by these researchers - both established senior investigators and their students."

--Thomas P Stossel, MD, American Cancer Society Professor of Medicine Harvard Medical School Director, Translational Medicine Unit and center for Medical Innovation Senior Physician, Hematology Division Brigham & Women's Hospital, Boston, MA, USA

"...a clearly written, concise, and comprehensive discussion of platelets and their disorders that will be useful to anyone whose professional activity involves these important little cells." --Journal of the American Medical Association "...If you field platelet questions, you should get this book..." - Valerie L. Ng, PhD, MD, Alameda County Medical Center/Highland Hospital, FOR DOODY'S (4 Stars) "This is a fantastic resource for anyone who treats patients with platelet disorders or is engaged in platelet or megakaryocyte-based research." - BRITISH JOURNAL OF HAEMATOLOGY REVIEWS OF THE FIRST EDITION "landmark...a useful, comprehensive reference" - New England Journal of Medicine "belongs on the bookshelf of every clinician who assesses patients with platelet disorders" - The Lancet "arguably the most complete compendium available on the subject that was once regarded as merely 'blood dust'." - British Journal of Haematology "a single-handed compilation of authoritative material" - Transfusion "a modern encyclopedia...stands out as the most comprehensive and up-to-date review of platelets yet published." - Journal of Vascular Surgery "beautifully organized" - American Journal of Clinical Pathology
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About Alan D. Michelson

Dr. Alan D. Michelson is Professor of Pediatrics and Professor of Medicine at Harvard Medical School in Boston, Massachusetts. He is also the Director of the Center for Platelet Research Studies and the Director of the Thrombosis Program and Anticoagulation Service at Children's Hospital Boston. After receiving his medical degree with honors from the University of Adelaide, Australia in 1974, Dr. Michelson continued his medical and research training on a Fulbright Scholarship at Children's Hospital Boston, Brigham and Women's Hospital, and Harvard Medical School. He has been the principal investigator on approximately 100 research grants and has published over 400 original research articles, original research abstracts, and invited reviews. Dr. Michelson has been an invited speaker at over 180 major medical conferences worldwide and has been an invited participant at numerous national and international consensus conferences and workshops, including Antithrombotic and Thrombolytic Therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. He is the inventor on two U.S. patents.
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