Photostability of Drug and Drug Formulations
This text discusses various aspects of the combination of drugs and light. Degradation processes, stabilization of photolabile drug substances within formulations, benefits from the combination of drugs and light, and testing of drug photoreactivity, are some of the topics discussed.
- Hardback | 405 pages
- 03 Sep 1996
- Taylor & Francis Ltd
- London, United Kingdom
Table of contents
Photochemical and phytophysical aspects of drug stability; technical requirements and equipment for photochemical stability and testing; standardization of photodegradation studies and kinetic treatment of photochemical reactions; is the photodecomposition of drugs predictable?; photodecomposition and stabilization of compounds in dosage forms; addressing the problems of light instability during formulation development; light activated drugs and drug formulations in drug targeting; benefits and adverse effects from the combination of drugs and light; screening of new drugs for ocular phototoxicity; the contribution of organic photochemistry to investigations of phototoxicity; in vitro screening of the photoreactivity of antimalarials - a test case; inconsistencies and deficiencies which exist in the current official regulations concerning the photolytic degredation of drugs; photostability testing - design and interpretation of tests on drug substances and dosage forms; mathematical models for studies of photochemical reactions; the application of photoacoustic spectroscopy to the photodegradation of drugs.
About Hanne Hjorth Tonnesen
Tonnesen; Hanne Hjorth University of Oslo, Norway,