Philosophy of Molecular Medicine

Philosophy of Molecular Medicine : Foundational Issues in Research and Practice

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Despite its prominence in scientific research, molecular medicine has not received sufficient attention by the philosophical community. Philosophy of Molecular Medicine: Foundational Issues in Theory and Practice aims at a systematic investigation of a number of foundational issues in the field of molecular medicine. The volume is organized around four broad modules focusing, respectively, on the following key aspects: What are the nature, scope and limits of molecular medicine? How does it provide explanations? How does it represent and model phenomena of interest? How does it infer new knowledge from data and experiments? The essays collected here, authored by prominent scientists and philosophers of science, focus on a handful of mainstream topics in the philosophical literature, such as causation, explanation, modeling, and scientific inference. These previously unpublished contributions shed new light on these traditional topics by integrating them with problems, methods, and results from three prominent areas of contemporary biomedical science: basic research, translational and clinical research, and clinical more

Product details

  • Paperback | 288 pages
  • 152 x 229mm
  • Taylor & Francis Ltd
  • London, United Kingdom
  • English
  • 3 Tables, black and white
  • 1138940682
  • 9781138940680

About Giovanni Boniolo

Giovanni Boniolo (degree in physics and in philosophy) is Professor of Philosophy of Science and Medical Humanities, at the Universita di Ferrara and Anne Boyksen Fellowship, at the Institute for Advanced Study, Technische Universitat Munchen. He has published 13 books (plus 12 books edited) and about 200 research articles. Marco J. Nathan (Ph.D. 2012, Columbia University) is Assistant Professor of Philosophy at the University of Denver. His work has been published in various philosophical and scientific journals, including Nous, Philosophy of Science, British Journal for Philosophy of Science, Nephrology Dialysis and Transplantation, Biology and Philosophy, and more

Table of contents

Introduction Giovanni Boniolo and Marco J. Nathan ã Part 1: Nature, Origins, and Scope Chap. 1: Molecular medicine: the clinical method enters the lab. What tumor heterogeneity and primary tumor culture teach us Giovanni Boniolo Chap. 2: Personalized Medicine: Historical Roots of a Medical Model Mariacarla Gadebusch Bondio and Francesco Sporing Chap. 3: From the concept of genetic disease to the geneticization of diseases: analyzing and solving the paradox of contemporary medical genetics Marie Darrason ã Part 2: Explanation Chap. 4: Molecular complexity: Why has psychiatry not been revolutionized by genomics (yet)? Mael Lemoine Chap. 5: How cancer spreads: reconceptualizing a disease Katherine E. Liu, Alan C. Love, and Michael Travisano Chap. 6: Evolutionary Perspectives on Molecular Medicine: Cancer from an Evolutionary Perspective Anya Plutynski ã Part 3: Representation and Modeling Chap. 7: Towards a Notion of Intervention in Big-Data Biology and Molecular Medicine Federico Boem and Emanuele Ratti Chap. 8: Pathways to the clinic: cancer stem cells and challenges for translational research Melinda Bonnie Fagan Chap. 9: Counterfactual Reasoning in Molecular Medicine Marco J. Nathan ã Part 4: Inference Chap. 10: Forms of Extrapolation in Molecular Medicine Pierre-Luc Germain and Tudor Baetu Chap. 11: Testing Oncological Treatments in the Era of Personalized Medicine David Teira Chap. 12: Opportunities and challenges of molecular epidemiology Federica Russo and Paolo Vineisshow more