Philosophy of Molecular Medicine

Philosophy of Molecular Medicine : Foundational Issues in Research and Practice

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Description

Philosophy of Molecular Medicine: Foundational Issues in Theory and Practice aims at a systematic investigation of a number of foundational issues in the field of molecular medicine. The volume is organized around four broad modules focusing, respectively, on the following key aspects: What are the nature, scope, and limits of molecular medicine? How does it provide explanations? How does it represent and model phenomena of interest? How does it infer new knowledge from data and experiments? The essays collected here, authored by prominent scientists and philosophers of science, focus on a handful of mainstream topics in the philosophical literature, such as causation, explanation, modeling, and scientific inference. These previously unpublished contributions shed new light on these traditional topics by integrating them with problems, methods, and results from three prominent areas of contemporary biomedical science: basic research, translational and clinical research, and clinical practice.
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Product details

  • Hardback | 288 pages
  • 152 x 229 x 22.86mm | 564g
  • ROUTLEDGE
  • London, United Kingdom
  • English
  • 11 Line drawings, black and white; 1 Halftones, black and white; 3 Tables, black and white
  • 1138940674
  • 9781138940673

Table of contents

Introduction


Giovanni Boniolo and Marco J. Nathan





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Part 1: Nature, Origins, and Scope





Chap. 1: Molecular medicine: the clinical method enters the lab. What tumor heterogeneity and primary tumor culture teach us


Giovanni Boniolo





Chap. 2: Personalized Medicine: Historical Roots of a Medical Model


Mariacarla Gadebusch Bondio and Francesco Spoering





Chap. 3: From the concept of genetic disease to the geneticization of diseases: analyzing and solving the paradox of contemporary medical genetics


Marie Darrason





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Part 2: Explanation





Chap. 4: Molecular complexity: Why has psychiatry not been revolutionized by genomics (yet)?


Mael Lemoine





Chap. 5: How cancer spreads: reconceptualizing a disease


Katherine E. Liu, Alan C. Love, and Michael Travisano





Chap. 6: Evolutionary Perspectives on Molecular Medicine: Cancer from an Evolutionary Perspective


Anya Plutynski





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Part 3: Representation and Modeling





Chap. 7: Towards a Notion of Intervention in Big-Data Biology and Molecular Medicine


Federico Boem and Emanuele Ratti





Chap. 8: Pathways to the clinic: cancer stem cells and challenges for translational research


Melinda Bonnie Fagan





Chap. 9: Counterfactual Reasoning in Molecular Medicine


Marco J. Nathan





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Part 4: Inference





Chap. 10: Forms of Extrapolation in Molecular Medicine


Pierre-Luc Germain and Tudor Baetu





Chap. 11: Testing Oncological Treatments in the Era of Personalized Medicine


David Teira





Chap. 12: Opportunities and challenges of molecular epidemiology


Federica Russo and Paolo Vineis
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About Marco J. Nathan

Giovanni Boniolo (degrees in Physics and in Philosophy) is Professor of Philosophy of Science and Medical Humanities at the Universita di Ferrara, and Anna Boyksen Fellow at the Institute for Advanced Study, Technische Universitat Munchen. He has published 13 books (plus 12 books edited) and about 200 research articles.





Marco J. Nathan is Assistant Professor of Philosophy at the University of Denver. His work has been published in various philosophical and scientific venues, including Nous, Philosophy of Science, British Journal for Philosophy of Science, Nephrology Dialysis and Transplantation, Biology and Philosophy, and Synthese.
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