The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently.
- Paperback | 832 pages
- 187.96 x 238.76 x 35.56mm | 1,587.57g
- 01 Sep 1999
- Elsevier Health Sciences
- CHURCHILL LIVINGSTONE
- London, United Kingdom
- 4th Revised edition
- 335 ills.
About Humphrey P. Rang
HP RangProfessor HP Rang obtained his first degree in Physiology at University College London, and went on to graduate in Medicine before moving to the Department of Pharmacology in Oxford. There he gained a DPhil, and wasappointed to a University Lectureship in Pharmacology and a Fellowship at Lincoln College, Oxford. He became Professor and Head of Department at St George's Hospital Medical School and later at University College London, and he was Director of the Novartis (formerly Sandoz) Institute for Medical Research, based at University College. Professor Rang was elected a Fellow of the RoyalSociety in 1980. Since retiring in 1999, he has worked as a consultant to pharmaceutical and biotechnology companies. He has published many research papers, mainly in the fields of receptor pharmacology and neuroscience.With Dr Maureen Dale he wrote the first edition of Pharmacology (1987),and Professor Jim Ritter became a co-author for the third and subsequent editions. He is currently preparing a new book on Drug Discovery, to be published by Harcourt.MM DaleDr Dale is Senior Teaching Fellow in the Department of Pharmacology of the University of Oxford. Having graduated in Medicine at the University of the Witwatersrand in Johannesburg, South Africa, she worked as a medical officer at a Health Centre for several years before joining the staff of medical school of the University of Natal. There she was responsible for establishing ab initio, the first course in experimental/clinical pharmacology in South Africa. Finding herself in profound disagreement with the 'apartheid' government in South Africa, she emigrated to the UK where she joined the Department of Pharmacology of University College London. There she gained a PhD in pharmacology and was, for many years, responsible for running the pharmacology course for medical students and the immunopharmacology course for final year science students.Dr Dale has been an editor of the British Journal of Pharmacology. Before retiring fromUCL in 1991, her research areas were the immunopharmacology of asthma and rheumatoid arthritis. JM RitterProfessor Jim Ritter is Head of the Department of Clinical Pharmacology at Guy's King's and St Thomas' School of Medicine (King's College, London, UK). His first degree was in Animal Physiology and he obtained a D Phil in Pharmacology before completing clinical medicine at the Radcliffe Infirmary (Oxford). His basic medical training was in Oxford, London and the Johns Hopkins Hospital (Baltimore, USA), where he was chief resident for two years. Subsequent specialist training in clinical pharmacology was at Hammersmith Hospital (London). He is an honorary consultant physician at Guy's and St Thomas' NHS Trust where he shares in the acute general medical take, and sees outpatients in the hypertension and vascular disease prevention clinics. His research is in human vascular pharmacology, especially of endothelium-derived mediators. He sat on the sub-committee on safety and efficacy of CSM, has chaired local and multicentre research ethics committees, and currently chairs the Thames Specialty Training Committee in Clinical Pharmacology. He is one of the two editors of the British Journal of Clinical Pharmacology.
"Rang & Dale are now due more praise for their new improved version of Pharmacology. As before the writing is excellent and surely undergraduates can master a subject when it is explained so lucidly and with evident enthusiasm. As a comprehensive textbook for pharmacy or pharmacology students it has few rivals. As a guide to help continuing education in modern pharmacology it should be both useful and enjoyable." British Journal of Hospital Medicine
Table of contents
Section 1 General Principles How drugs act: general principles How drugs act: molecular aspects Method and measurement in pharmacology Absorption and distribution of drugs Drug elimination and pharmokinetics Section 2 Chemical Mediators Chemical mediators and the autonomic nervous system Cholinergic transmission Noradrenergic transmission Other peripheral mediators: 5-hydroxytryptamine and purines Peptides and proteins as mediators Nitric oxide Local hormones, inflammation and allergy Anti-inflammatory and immunosuppressant drugs Section 3 Drugs Affecting Major Organ Systems The heart The vascular system Atherosclerosis and lipoprotein metabolism Haemostasis and thrombosis The haemopoietic system The respiratory system The kidney The gastrointestinal system The endocrine pancreas and the control of blood glucose Obesity The pituitary and adrenal cortex The thyroid The reproductive system Bone metabolism Section 4 The Central Nervous System Chemical transmission and drug action in the central nervous system Amino acid transmitters Other transmitters and modulators Neurodegenerative disorders General anaesthetic drugs Anxiolytic and hypnotic drugs Antipsychotic drugs Drugs used in affective disorders Antiepileptic drugs and centrally acting muscle relaxants Analgesic drugs Central nervous system stimulants and psychotomimetic drugs Drug dependence and drug abuse Local anaesthetics and other drugs that affect ion channels Section 5 Chemotherapy of Infectious and Malignant Disease Basic principles of chemotherapy Cancer chemotherapy Antibacterial drugs Antiviral drugs Antifungal drugs Ant