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This text describes the mechanisms by which drugs act and relates these to their overall pharmacological effects and clinical uses. This new edition emphasizes the chemical structures of those drugs for which knowledge of structure-activity relationships enhances appreciation of how the drugs act. It also includes new drugs, including drugs used not in therapy but in research. As regards other new material, the authors have taken into account new agents and also extensions of basic knowledge which presage further drug development. There are new chapters on 5-HT, on peptides as mediators, and on the control of lipoprotein metabolism. The references have been extended with the needs of postgraduate and university teachers in mind. Key points are included in relevant sections to help students' revision, while features retained from the first edition include the brief introductory summaries of relevant physiological and biochemical factors at the beginning of the chapter which form a basis for subsequent treatment.
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Product details

  • Paperback | 968 pages
  • 187.96 x 243.84 x 40.64mm | 1,814.36g
  • Elsevier Health Sciences
  • London, United Kingdom
  • English
  • Revised
  • 2nd Revised edition
  • 400 line drawings
  • 0443041105
  • 9780443041105

Table of contents

Part 1 General principles: how drugs act - general principles; how drugs act - molecular aspects; measurement in pharmacology; absorption, distribution and fate of drugs; individual variation and drug interaction. Part 2 Chemical mediators: chemical transmission and the autonomic nervous system; cholinergic transmission; adrenergic transmission; other peripheral mediators - 5-hydroxytryptamine and purines; peptides as mediators; local hormones, inflammation and allergy; drugs used to suppress inflammatory and immune responses. Part 3 Drugs affecting major organ systems: the heart; the circulation; control of lipoprotein metabolism; haemostasis and thrombosis; the respiratory system; the kidney; the gastro-intestinal tract; the endocrine system; the reproductive system; the haemopoietic system. Part 4 The central nervous system: chemical transmission and drug action in the central nervous system; general anaesthetic agents; anxiolytic and hypnotic drugs; neuroleptic drugs; drugs used in affective disorders; drugs used in treating motor disorders; analgesic drugs; central nervous system stimulants and psychotomimetic drugs; local anaesthetics and other drugs that affect excitable membranes. Part 5 Chemotherapy: basic principles of chemotherapy; cancer chemotherapy; antibacterial agents; antiviral drugs; antifungal drugs; antiprotozoal drugs; antihelminthic drugs. Part 6 General topics: non-therapeutic drugs - nicotine, alcohol, cannabis, cocaine, harmful affects of drugs.
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Rating details

411 ratings
4.17 out of 5 stars
5 51% (208)
4 27% (110)
3 15% (60)
2 5% (22)
1 3% (11)
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