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Genes are important modifiers of the human response to drugs, hormones, and toxins. Medical patients and healthy individuals alike display significant differences in response and suffer adverse effects as a result of exposure to many therapeutic agents and occupational chemicals. In this new edition Weber brings together laboratory methods and epidemiological studies in defining the role of heredity in human drug response. The book is divided into two major sections, one covering pharmacogenetic concepts and the second the application of those concepts. The first edition was published in 1997, and a vast amount of new information about the genetics of human drug response has accumulated since then. In just five years, we have moved from mapping the first complete sequence of a free-living organism to a working draft of the human genome. The application of tools for analysing genetic variation and the maturation of the human genome initiative has provided a wealth of primary genetic information and functional genomic data to fuel out understanding of genetic variation. Today, pharmacogenetics comprises a well-integrated network of physicians and scientists worldwide who are attempting to identify variations in human disease and drug response and how they might use this information to discover new, more effective drugs and avoid unwanted drug responses. Dr Weber is completely overhauling and updating all discussions to reflect the enormous changes of the past 10 years. As pharmacogenetics is an even hotter topic than it was in 1997, this new book should have even wider appeal in its second more

Product details

  • Hardback | 448 pages
  • 152.4 x 236.22 x 22.86mm | 725.74g
  • Oxford University Press Inc
  • New York, United States
  • English
  • Revised
  • 2nd Revised edition
  • 4 colour & 52 black and white line illustrations
  • 0195341511
  • 9780195341515

Review quote

..".an introduction to all facets of pharmacogenetics for physicians, pharmacists, epidemiologists and other professionals in the life sciences. It is also a very useful collection of material for professors of pharmacology to use in preparing for lectures for every level of student... Compared to other pharmacogenetic textbooks, this one is unique in its inclusion of a chapter on epigenetics."--Doody's"Dr. Wendell Weber provides a significant update to his first edition, which appeared in 1997...This book serves as an excellent introduction to the field and includes enough detail to serve as a helpful reference as well...This book provides an initial step in the right direction toward better understanding of this complex and expanding field." -- Jacob William Shatzer, MDiv, Bioethics Press Ltdshow more

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