Pharmaceutical Toxicology

Pharmaceutical Toxicology

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The "ULLA" series is a new and innovative series of introductory textbooks for postgraduate students in the pharmaceutical sciences. This new series is produced by the ULLA Consortium (European University Consortium for Advanced Pharmaceutical Education and Research). The Consortium is a European academic collaboration in research and teaching of the pharmaceutical sciences that is constantly growing and expanding. Before a drug substance can be tested in man, a set of toxicology studies must be carried out in animals and in vitro to ensure, as far as possible, safety for the test subjects. Toxicity studies involve assessment of acute, repeated dose and chronic toxicities, evaluation of potential effects on vital organs, reproductive and developmental toxicity studies, and carcinogenicity studies. This book covers a limited number of areas of drug toxicity which address the major issues including registration requirements of new drugs and pharmacovigilance. It also provides an overview of the methodology and requirements of pre-clinical safety assessment of new medicines.
Mechanisms by which drugs cause toxic effects in living organisms, and problems in the toxicity of specific agents are covered, as are regulatory issues, pharmacovigilence, and clinical toxicology. There is no other textbook at this level dedicated to pharmaceutical toxicology, and this new title in the "ULLA" series fills a definite gap in the market.
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Product details

  • Paperback | 280 pages
  • 156 x 230 x 16mm | 421.85g
  • Pharmaceutical Press
  • London, United Kingdom
  • English
  • 0853695938
  • 9780853695936
  • 618,722

Table of contents

1. General toxicology; 2. Drug metabolism: inactivation and bioactivation of xenobioptics; 3. Molecular and cellular mechanisms of toxicity; 4. Teratology; 5. Genotoxicity; 6. Carcinogenicity of drugs; 7. Liver toxicity; 8. Kidney toxicity; 9. Toxicology in the respiratory system; 10. Immunotoxicity; 11. Clinical toxicology; 12. Safety assessment of pharmaceuticals: regulatory aspects; 13. Pharmacovigilance.
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Review quote

'...this is a great little book...the text is aimed primarily at new PHD students in the pharmaceutical and related sciences but could equally well serve taught postgraduate students on toxicology, clinical pharmacology, drug development and safety or similar courses. The book 'does exactly what it says on the tin' and will definitely whet the appetite of enthusiastic young researchers for toxicology.'Heather M Wallace, Summer 2007 issue of the British Toxicology Society Newsletter -- Heather M Wallace * British Toxicology Society Newsletter * 'The text is well written, concise and easy to understand with informative and helpful illustrations, figures and serves as an excellent companion to pharmacology textbooks, dealing with the issues relevant for assessing the safety of new drugs...a good starting point for the novice toxicologist, ambitious undergraduate student or graduate students working in the pharmaceutical sciences.'Irish Pharmacy Journal, November 2006, p418 * Irish Pharmacy Journal *
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