Pharmaceutical Powder Compaction Technology, Second Edition

Pharmaceutical Powder Compaction Technology, Second Edition

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Description

Compaction of powder constituents-both active ingredient and excipients-is examined to ensure consistent and reproducible disintegration and dispersion profiles. Revised to reflect modern pharmaceutical compacting techniques, this second edition of Pharmaceutical Powder Compaction Technology guides pharmaceutical engineers, formulation scientists, and product development and quality assurance personnel through the compaction formulation process and application.


This unique reference covers:












The physical structure of pharmaceutical compacts
Bonding phenomena that occur during powder compaction
Compression mechanisms of pharmaceutical particles
Theories and basic principles of powder compaction









New topics include:












Compaction data analysis techniques
The migration of powder constituents into commercial manufacture
Instrumentation for compaction
Compaction functionality testing, which is likely to become a USP requirement
Design space for compaction
Metrics required for scalability in tablet compression
Interactive compaction and preformulation database for commonly used excipients
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Product details

  • Hardback | 344 pages
  • 177.8 x 246.38 x 27.94mm | 771.1g
  • CRC Press Inc
  • Bosa Roca, United States
  • English
  • New edition
  • 2nd New edition
  • 165 Line drawings, black and white; 41 Halftones, black and white; 205 Illustrations, black and white
  • 142008917X
  • 9781420089172
  • 1,223,509

Table of contents

THEORY OF COMPACTION
Intermolecular Bonding Forces: where materials and process come together
Graham Buckton
COMPACTION DATA ANALYSIS TECHNIQUES
Viscoelastic Models
Susan K. Lum
Application of Percolation Theory and Fractal Geometry to Tablet Compaction
Hans Leuenberger, Maxim Puchkov, Ruth Leu-Marseiler, Jean-Daniel Bonny, Michael N. Leuenberger
Post Compaction Data Analysis Techniques
Gary Bubb
INTRUMENTATION AND EQUIPMENT IN COMPACTION
Tablet Press Instrumentation in the Research and Development Environment
Gary Bubb
Advanced Compaction Research Equipment: Compaction Simulators
Colleen Ruegger, Metin Celik
Compactability Functionality Test
Esay Okutgen
ROLE OF COMPACTION IN THE FORMULATION AND PROCESS DEVELOPMENT OF TABLETTING
Compaction Properties of Directly Compressible Materials
Gerad K. Bolhuis, Hans de Waard
Lubrication Issues in Direct Compaction
Gerad K. Bolhuis, Arne W. Hoelzer
Crystal Engineering and Particle Design for the Powder Compaction Process
Anant Paradka, Peter York
Compaction of Combination Products
Carl T. Allenspach, Erika A. Zannou
Quality by Design and Compression
Chris Balducci, Rosario LoBrutto, Alan Royce, James Cheney, Dong Xiang, Olivia Darmuzey, Hedinn Valthorsson
Expert Systems and Their Use in Pharmaceutical Applications
Metin Celik
Press-To-Press Scalability and Transitioning Factors
Gary Bubb
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