Pharmaceutical Aspects of Oligonucleotides
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Pharmaceutical Aspects of Oligonucleotides

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Description

Oligonucleotides diffuse poorly through biological barriers, including cell membranes. They are also rapidly degraded in vivo by nucleuses. Aiming to improve the administration of compounds, the book studies the development of nucleotide chemistry.show more

Product details

  • Hardback | 336 pages
  • 178 x 246 x 26mm | 798.34g
  • Taylor & Francis Ltd
  • London, United Kingdom
  • English
  • New.
  • 59 b&w illustrations
  • 074840841X
  • 9780748408412

Table of contents

1. Mechanisms of Action of Antisense Oligonucleotides D.M. Tidd and R.V. Giles 2. Chemistry of Oligonucleotides J.W. Engels and E. Uhlmann 3. The Oligonucleotide Prodrug Approach: The Pro-oligonucleotides F. Morvan, J.-J. Vasseur, E. Vives, B. Rayner and J.-L. Imbach 4. Peptide Nucleic Acids P.E. Nielsen 5. Peptide-mediated Delivery of Oligonucleotides E. Vives and B. Lebleu 6. Polymeric Nanoparticles and Microparticles as Carriers for Antisense Oligonucleotides E. Fattal and P.show more