Personalized Epigenetics
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Personalized Epigenetics

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Description

Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy.

The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics.

Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.
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Product details

  • Hardback | 610 pages
  • 157.48 x 236.22 x 25.4mm | 975.22g
  • Academic Press Inc
  • San Diego, United States
  • English
  • Illustrated; Illustrations, unspecified
  • 0124201350
  • 9780124201354
  • 1,771,311

Table of contents

Section I: Overview

1. Epigenetics of Personalized Medicine

Section II: Epigenetic Variations Among Individuals

2. Inter-individual Variability of DNA Methylation

3. Differences in Histone Modifications Between Individuals

4. Individual Noncoding RNA Variations: Their Role in Shaping and Maintaining the Epigenetic Landscape

5. Personalized Epigenetics: Analysis and Interpretation of DNA Methylation Variation

Section III: Bioinformatics of Personalized Epigenetics

6. Computational Methods in Epigenetics

Section IV: Diagnostic and Prognostic Epigenetic Approaches to Personalized Medicine

7. Epigenetic Biomarkers in Personalized Medicine

8. Epigenetic `Fingerprint'

9. Epigenetics of Personalized Toxicology

Section V: Environmental Personalized Epigenetics

10. Environmental Contaminants and their Impacts on the Epigenome

11. Nutriepigenomics: Personalized Nutrition Meets Epigenetics

Section VI. Pharmacology and Drug Development of Personalized Epigenetics

12. Personalized Pharmacoepigenomics

13. Personalized Medicine and Epigenetic Drug Development

Section VII: Personalized Epigenetics of Disorders and Disease Management

14. Epigenetics and Personalized Pain Management

15. Understanding Inter-individual Epigenetic Variations in Obesity and its Management

16. Epigenetic Modification of miRNAs in Cancer

17. Managing Autoimmune Disorders Through Personalized Epigenetic Approaches

18. Cardiovascular Diseases and Personalized Epigenetics

Section VIII: Challenges and Future Directions

19. Future Challenges and Prospects for Personalized Epigenetics
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About Trygve Tollefsbol

Professor of Biology, University of Alabama at Birmingham, Birmingham, AL. Dr. Tollefsbol is a Professor of Biology and a Senior Scientist in the Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999 and a Steering Committee Member of the UAB Center for Aging. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor's degree in Biology from the University of Houston. He has received prior funding from the NIA, NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources. The Glenn Foundation for Medical Research funding was unsolicited and was awarded to Dr. Tollefsbol for lifetime contributions to the field of aging. In 2006 Dr. Tollefsbol was selected and highlighted as part of the 25th anniversary of the AFAR for significant contributions to aging research. Dr. Tollefsbol's research interests have covered a wide range of topics such as aging, epigenetics, nutrition, cancer, telomerase, and caloric restriction. Work from his laboratory has been featured in Women's Health magazine, Shape magazine, and the AICR Newsletter and Dr. Tollefsbol has been a Scientist in the Spotlight in ScienceNow. Currently he serves as an Associate Editor for Frontiers in Epigenomics and is on the Editorial Boards of the international journals Open Longevity Science, Epigenetics of Diabetes and Obesity, Molecular Biotechnology and Clinical Epigenetics. He is also a contributing Editor of Lewin's GENES X classic textbook. Over 25 of the publications from Dr. Tollefsbol's laboratory have received national or international accolades such as best paper award, selection for press release by the journal editors and featured on the journal homepage. Dr. Tollefsbol has been invited to give presentations on his research in many countries including Germany, China, Italy, Switzerland, France and The Netherlands as well as at various leading institutions in the US such as Harvard Medical School, Tufts University and the University of California at San Francisco. His research has received considerable media attention both nationally and internationally through television, newspaper and radio venues and has been highlighted in eScience News and ScienceDaily. He has ten books which have been published or are in progress and a recent book on "Epigenetics of Aging" that Dr. Tollefsbol co-authored and edited was highlighted in Nature.
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