Peptide-Lipid Interactions: Volume 52

Peptide-Lipid Interactions: Volume 52

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This volume contains a comprehensive overview of peptide-lipid interactions by leading researchers. The first part covers theoretical concepts, experimental considerations, and thermodynamics. The second part presents new results obtained through site-directed EPR, electron microscopy, NMR, isothermal calorimetry, and fluorescence quenching. The final part covers problems of biological interest, including signal transduction, membrane transport, fusion, and adhesion.
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Product details

  • Paperback | 601 pages
  • 152 x 229 x 25.4mm | 830g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0126438714
  • 9780126438710

Table of contents

PART I: Biophysical Techniques for Analyzing Peptide-Lipid Interactions
Peptide-Membrane Interactions Determined Using Site Directed Spin Labeling.
Isothermal Titration Calorimetry to Study Interactions Between Peptides and Lipid Membranes.
Infrared Reflection-Absorption Spectroscopy of Lipids, Peptides, and Proteins in Aqueous
Measuring the Depth of Amino Acid Residues in Membrane-Inserted Peptides by Fluorescence
Surface-sensitive X-ray and Neutron Scattering Characterization of Planar Lipid Model
membranes and Lipid/Peptide Interactions.
Lipid-Peptide Interactions Investigated by NMR.
Peptide-Lipid Interactions in Supported Monolayers and Bilayers.

Part II: Theoretical and Computational Analyses of Peptide-Lipid Interactions
Free Energy Determinants of Peptide Association with Lipid Bilayers.
Investigating Ion Channels Using Computational Methods.

Part III: Experimental Investigations of Peptide-Lipid Interactions
The Role of Electrostatic and Nonpolar Interactions in the Association of Peripheral Proteins with Membranes.
The Energetics of Peptide-Lipid Interactions: Modulation by Interfacial Dipoles and Cholesterol.
Transmembrane Alpha Helices.
Lipidated Peptides as Tools to Understand the Membrane Interactions of Lipid-modified Proteins.
Experimental and Computational Studies of the Interactions of Amphipathic Peptides with Lipid Surfaces.
Interactions of pH-Sensitive Peptides and Polymers with Lipid Bilayers: Binding and Membrane Stability.
The Hydrophobicity Threshold for Peptide Insertion into Membranes.

Part IV: Specialized Topics of Biological Relevance
Signal Sequence Function in the Mammalian Endoplasmic Reticulum: A Biological Perspective.
The Process of Membrane Fusion: Nipples, Hemifusion Pores, and Pore Growth.
Prenylation of CaaX-Type Proteins: Basic Principles through Clinical Applications.
Peptides as Probes of Protein-Protein Interactions Involved in Neurotransmitter Release.
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Review quote

"...a highy quality book with authoritative reviews, useful citations, and adequate illustrative material. The field is of increasing interest and the contribution is timely."
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About Sidney A. Simon

Edited by Sidney A. Simon
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