Particulate Interactions in Dry Powder Formulation for Inhalation

Particulate Interactions in Dry Powder Formulation for Inhalation

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Description

Interactions between drug particulates are crucial in determining drug dispersion and deaggregation, and ultimately delivery efficiency. This book combines principles and factors in pharmaceutical powder technology, critically reviews some of the studies carried out in dry powder formulation development, and proposes possible strategies for improving their efficiency. The majority of these principles are applicable to other pharmaceutical solid dosage forms (e.g. tablets and capsules).show more

Product details

  • Hardback | 264 pages
  • 184 x 264 x 38mm | 919.99g
  • Taylor & Francis Ltd
  • Informa Healthcare
  • London, England, United Kingdom
  • English
  • 40 b&w line drawings
  • 0748409602
  • 9780748409600

Back cover copy

With the current trend for phasing out propellant-based aerosols, attention is now focused on the use of dry powder inhalers for drug delivery to the airways. Dry powder formulations have the twin advantages of environmental-friendliness and ease of use. This book addresses the problem of optimising dry powder drug formulations for effective delivery throughout the lungs.Particulate interactions are crucial in determining drug dispersion and deaggregation, and ultimately the delivery efficiency of dry powder inhalers. This book combines principles established in surface and colloidal chemistry, with pharmaceutical powder technology. It discusses some of the factors affecting particulate interactions, and particle-fluid interaction in the respiratory tract. Second, it critically reviews some of the studies carried out in dry powder formulation development, and third, it proposes possible strategies in improving dry powder inhaler efficiency. The majority of these principles are applicable to other pharmaceutical solid dosage forms such as tablets and capsules.Appealing to both research students and pharmaceutical professionals, Particulate Interactions in Dry Powder Formulations for Inhalation provides the most comprehensive single-volume coverage in this area.show more

Table of contents

1. Interparticulate Forces 2. Interparticulate Forces in Pharmaceutical Powders 3. Medicinal Aerosols 4. Particle Interactions with Air Streams 5. Particulate Interactions in Dry Powder Aerosols 6. Measurement of Cohesion, Adhesion and Dispersion of Powders 7. Physical Characterisation of Pharmaceutical Powdersshow more