Paradigms of Neural Injury: Paradigms of Neural Injury: Vol.30 Volume 30
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Paradigms of Neural Injury: Paradigms of Neural Injury: Vol.30 Volume 30

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Description

This volume includes paradigms, model systems, and techniques for the study of dysfunctions in the nervous system. The advantages and disadvantages of the approaches presented are critically discussed.
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Product details

  • Hardback | 335 pages
  • 194.1 x 240.5 x 21.3mm | 910.7g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0121853004
  • 9780121853006

Back cover copy

The classic perturbation paradigms for the study of the nervous system date to the turn of the century. They relied on the augmentation of tissue present and the removal of tissues of interest, followed by careful microscopic work dependent on artfully conceived tissue fixation and staining protocols.
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About Saurabh Jha

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize) and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine in 2012. Conn is a previous member of Council for the American Society for Cell Biology and the Endocrine Society and is a prior President of the Endocrine Society, during which time he founded the Hormone Foundation and worked with political leadership to heighten the public's awareness of diabetes. Conn's students and fellows have gone on to become leaders in industry and academia. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science. He is the co-author of The Animal Research War (2008) and many articles for the public and academic community on the value of animal research and the dangers posed by animal extremism. His op/eds have appeared in The Washington Post, The LA Times, The Wall Street Journal, the Des Moines Register, and elsewhere. Conn consults with organizations that are influenced by animal extremism and with universities and companies facing challenges from these groups.
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Table of contents

Paradigms for Study of Neurotrophin Effects in Oxidant Injury, G.R. Jackson and J.R. Perez-Polo.
Nitric Oxide Toxicity in Central Nervous System Cultures, V.L. Dawson and T.M. Dawson.
Development of in Vitro Injury Models for Oligodendroglia, A. Espinosa, P. Zhao, and J. de Vellis.
Glia Models to Study Glial Cell Cytotoxicity, A. Vernadakis and M.S. Kentroti.
Rodent Glioma Models, W.W. Maggio.
Peripheral Lesioning of Olfacory System: Expression of Neurotrophin Receptors, C.P. Turner and J.R. Perez-Polo.
Basal Forebrain Cholinergic Lesions and Complete Transection of Septal-Hippocampal Pathway, L.R. Williams.
Neurochemical Lesions: Tools for Functional Assessment of Serotonin Neuronal Systems, J.M. Lakoski, B.J. Keck, and A. Dugar.
Cerebral Glucose/Energy Metabolism: Valid Techniques in Humans and Animals, S. Hoyer.
Heavy Metal Effects on Glia, E. Tiffany-Castiglioni, M.E. Legare, L.A. Schneider, E.D. Harris, R. Barhoumi, J. Zmudzki, Y. Qian, and R.C. Burghardt.
Source, Metabolism, and Function of Cysteine and Glutathione in the Central Nervous System, D.K. Rassin.
Magnetic Resonance Spectroscopy of Neural Tissue, R.J. McClure, K.Panchaligam, W.E. Klunk, and J.W. Pettegrew.
Acute Stroke Diagnosis with Magnetic Resonance Imaging, S.C. Jones, N.C. Huang, M.J. Quast, A.D. Perez-Trepechio, G.R. Hillman, and T.A. Kent.
Evaluation of Free Radical-Initiated Oxidant Events within the Nervous System, S.C. Bondy.
Exogenous Administration of Cytokines into the Central Nervous System: Analysis of Alterations in Cell Morphology and Molecular Expression, M.A. Kahn and J. de Vellis.
Animal Models to Produce Cortical Cholinergic Dysfunction, R. Schliebs and V. Bigl.
In Vitro Studies of Liposome-Mediated Gene Transfection, K. Yang, J.R. Perez-Polo, F. Faustinella, G. Taglialatela, and R.L. Hayes.
Construction and Analysis of Transgenic Mice Expressing Amyloidogenic Fragments of Alzheimer Amyloid Protein Precursor, R.L. Neve and F.M. Boyce.
Golgi Technique Used to Study Stress and Glucocorticoid Effects on Hippocampal Neuronal Morphology, A.M. Magarinos, E. Fuchs, G. Flugge, and B.S. McEwin.
Index.
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Review quote

Praise for the Series: "Well-written, clear and detailed...The authors do indeed offer the 'fine detail, tricks and short cuts' not usually found in the written word." --Trends in Neurosciences
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