PNH and the GPI-Linked Proteins

PNH and the GPI-Linked Proteins

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Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays--based on the chemistry of the proteins--can be applied to many patients.
Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mechanism of hemolysis, the biochemistry of glycosylphosphoinositol anchors, and the chemistry and biophysics of GPI-anchored proteins.
This unique and timely volume will have a wide audience, including hematologists and oncologists with a clinical interest in this disease, as well as basic biochemists, immunologists, and cell biologists studying this class of proteins.
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Product details

  • Hardback | 279 pages
  • 186.4 x 263.1 x 22.4mm | 791.26g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0127729402
  • 9780127729404

About Neal S. Young

Neal S. Young is Chief of the Hematology Branch of the National Heart, Lung, and Blood Institute at the National Institutes of Health, Bethesda, Maryland.
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