Overexpression and Knockout of Cytokines in Transgenic Mice
Cytokines are a steadily growing family of molecules which play a major role in intercellular communication. Key questions for the cytokine researcher today include 'which cytokines are involved in the pathophysiology of a disease or immune response', 'when do these cytokines function' and 'which of their many activities are relevant in vitro. The intricate ways in which they act, often with the exhibition of pleiotropic or synergistic effects, make the study of cytokine biology complicated, and the results potentially ambiguous using conventional systems. As a consequence, many investigators are now utilizing the powerful tools of transgenic technology to address some of these questions. Written by the leading authorities in the field, this book describes the achievements realized so far, and clearly demonstrates the feasibility of using this approach to study the expression of this group of biologically important substances.
- Hardback | 191 pages
- 148 x 224 x 16mm | 399.16g
- 01 Nov 1994
- Elsevier Science Publishing Co Inc
- Academic Press Inc
- San Diego, United States
Table of contents
Strategies for Modulation of Interleukin-1 in Vivo: Knockout and Transgenics. Production of Interleukin-2 and Its Role in Autoimmunity. Interleukin-2 Overexpression and Deprivation: Consequences for Lymphopoiesis and T Cell Function. Interleukin-4-Expressing Transgenic Mice: In Vivo Models for Studying the Actions of a Cytokine. Interleukin-5 Activity in Vivo. Interleukin-6 Transgenic Mouse: A Model of Chronic Inflammatory Proliferative Disease. Leukemia Inhibitory Factor and Mammalian Development. Lymphopoiesis in Mice Homozygous for an Interleukin-7 Transgene. In Vivo Interactions with Abnormal Interleukin-4 of Ckit Receptor Expression. Expression and Knockout of Interferons in Transgenic Mice. Human Erythropoietin Gene Expression in Transgenic Mice. The Importance of Transforming Growth Factor-B1 in Immunological Homeostasis as Revealed By Gene Ablation in Mice. Granulocyte-Macrophage Colony Stimulating Factor Transgenic Mice.