Osteogenesis Imperfecta

Osteogenesis Imperfecta : A Translational Approach to Brittle Bone Disease

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Description

Osteogenesis Imperfecta is the first translational reference professionals can turn to for a source of comprehensive information on this disorder. Although several reviews of the field have been published in various journals, there is no other single source for a compendium of current information. Separate chapters discuss each of the several clinical features of OI. Ethical issues related to OI are discussed, as is the importance of nutrition in managing the OI child and the OI adult. The role of physical medicine and rehabilitation for OI patients is also presented, along with the current status of OI medical treatment and the prospects for genetic engineering in the future. The text also provides the orthopedic surgeon with an advanced discussion of surgical techniques applicable to OI.
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Product details

  • Hardback | 578 pages
  • 218.44 x 274.32 x 33.02mm | 1,882.4g
  • Academic Press Inc
  • San Diego, United States
  • English
  • New
  • 0123971659
  • 9780123971654

Table of contents

Foreword

Acknowledgments

List of Contributors

Section 1: INTRODUCTION

Section 2: BONE BIOLOGY, STRUCTURE AND BIOCHEMISTRY

Section 3: CLINICAL AND MOLECULAR GENETICS OF OSTEOGENESIS IMPERFECTA

Section 4: COL1A1 AND COL1A2 MUTATIONS

Section 5: ANIMAL MODELS OF OSTEOGENESIS IMPERFECTA

Section 6: BRITTLE BONE OVERLAP PHENOTYPES: TGF-BETA MUTATIONS AND BONE

Section 7: CLINICAL ASPECTS OF OSTEOGENESIS IMPERFECTA

Section 8: ORGAN INVOLVEMENT IN OSTEOGENESIS IMPERFECTA

Chapter 9: ORTHOPEDICS

Section 10: PHYSICAL MEDICINE AND REHABILITATION

Section 11: PHARMACOLOGIC TREATMENT OF OSTEOGENESIS IMPERFECTA

Section 12: GENETIC APPROACH TO TREATMENT OF OSTEOGENESIS IMPERFECTA

Index
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Review quote

"Shapiro..., Byers, Glorieux, and Sponseller compile 58 chapters by an international group of orthopedists, geneticists, bone specialists, and other physicians and researchers, who describe osteogenesis imperfecta. They address the basic science and clinical practice, as well as future research and its relevance to treatment and care, for basic scientists and clinicians."--Reference & Research Book News, December 2013 "A monumental nearly 600 page textbook about OI has recently been published. This comprehensive reference is a collection of chapters by an international group of physicians and researchers...Their goal was to bring together in one volume the latest information about the biochemistry, genetics, research questions and treatments available to manage OI in children and adults. A special feature is an advanced discussion of surgical techniques applicable to OI."--OI Foundation E-News, September 2013
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About Jay R. Shapiro

Dr. Jay R. Shapiro is a graduate of Franklin and Marshall College and the Boston University School of Medicine. He serves as Professor in the Department of Physical Medicine and Rehabilitation and Director of the Bone and Osteogenesis Imperfecta Department at the Kennedy Krieger Institute. He served as Director of the General Clinical Research Center at Johns Hopkins University and is on the Medical Advisory Committee of the Osteogenesis Imperfecta Foundation. Dr. Shapiro also served as the Chief for the Bone Team of the National Space Biomedical Research Institute. Dr. Shapiro has specialty interests in endocrine, metabolic and genetic disorders of bone. Current research activities include: heart disease in adult osteogenesis imperfecta, the effect of nutrition on bone growth in osteogenesis imperfecta, osteoporosis in Rett syndrome and a study of the effects of bisphosphonate treatment during microgravity on the International Space Station (NASA).
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