The Origins of Genome Architecture

The Origins of Genome Architecture

4.41 (39 ratings by Goodreads)
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Description

The availability of genomic blueprints for hundreds of species has led to a transformation in biology, encouraging the proliferation of adaptive arguments for the evolution of genomic features. This text explains why the details matter and presents a framework for how the architectural diversity of eukaryotic genomes and genes came to arise.
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Product details

  • Hardback | 389 pages
  • 182.9 x 238.8 x 30.5mm | 1,224.71g
  • New York, United States
  • English
  • 2007
  • 389 p.
  • 0878934847
  • 9780878934843
  • 392,088

Table of contents

The Origin of Eukaryotes.- Genome Size and Organismal Complexity.- The Human Genome.- Why Population Size Matters.- Three Keys to Chromosomal Integrity.- The Nucleotide-composition Landscape.- Mobile Genetic Elements.- Genomic Expansion by Gene Duplication.- Genes in Pieces.- Transcription and Regulatory-region Complexity.- Expansion and Contraction of Organelle Genomes.- Sex Chromosome Evolution.- Genomfart.
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Review quote

Lynch presents a synthesis of molecular genetics and evolutionary biology with a goal of driving new interdisciplinary research and understanding. He succeeds admirably. This extremely interesting book presents genomic evolution in a comprehensive manner and with different perspectives. What makes this volume so useful is that each chapter presents not only what and how, but also why (and why it matters). This book will appeal to everyone interested in genetics,
molecular biology, and evolution. It is highly recommended." * D. Carroll, Choice * This is a truly remarkable book, which will forever change your view of evolutionary biology. Anyone with even tangential interest in evolution needs to read the preface, epilogue, and especially the fourth chapter on population size. Lynch takes a detailed knowledge of molecular genetics and genomics, combined with a refined fluency in population genetics, to create sound sweeping descriptions and predictions about evolution. Read Lynch's book, have your students
read it, and let's revise our views of evolution." * Root Gorelick, Plant Science Bulletin * This volume would be an excellent foundation for an upper-level undergraduate course or a graduate seminar. It has become increasingly clear that a blind reliance on the explanatory power of natural selection has led to a lot of "sloppy thinking" and this book is a start toward clearing up some of this problem." * Richard J. Mural, The Quarterly Review of Biology * The book's first twelve chapters are a must-read for anyone interested in the evolution of genomes. As a whole, Origins of Genome Architecture represents a serious, valiant, and highly scholarly attempt at making sense of the new data provided by the genomic revolution. To that aim, Lynch deploys the full array of conceptual tools that make up the modern synthesis paradigm in evolutionary biology." * Massimo Pigliucci, Science * If you want a good summary of what genomics has revealed about genome architecture over the last two decades, merged with a nontechnical exposition of the relevant principles of population genetics, this is the book to get." * Daniel Hartl, Nature Genetics * This book is a must-read for every genome researcher. It is the most up-to-date and thorough summary of genome evolution published. Almost every page introduces interesting, unanswered problems, making it a gold mine for graduate students in search of a thesis topic." * Axel Meyer, Nature *
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About Bruce Walsh

MICHAEL LYNCH is a Distinguished Professor in the Department of Biology at Indiana University, Bloomington, USA.BRUCE WALSH is a Professor in the Department of Ecology and Evolutionary Biology at the University of Arizona, USA.
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Rating details

39 ratings
4.41 out of 5 stars
5 51% (20)
4 38% (15)
3 10% (4)
2 0% (0)
1 0% (0)
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