The Organic Chemistry of Biological Pathways
The Organic Chemistry of Biological Pathways provides a contemporary and authoritative treatment of the molecular logic of the chemistry of life...The authors have chosen to organize the text not by organic reaction type but by metabolic pathway. Doing so allows them to explain not only the chemistry of any given step but also the molecular logic of the entire pathway. Readers thus gain a deeper understanding of how and why the organic molecules of life undergo their sequential transformations and interconversions. To integrate the information from earlier chapters, as well as tie in traditional modes of organic reaction classification, the authors conclude with a summary chapter of the most common reaction types encountered in metabolism.
- Hardback | 512 pages
- 190.5 x 238.8 x 35.6mm | 1,383.47g
- 11 Feb 2005
- W.H.Freeman & Co Ltd
- New York, United States
- 5 colour illustrations
The book's greatest strength is its emphasis on the conceptual unity of organic chemistry and biochemistry. The chemical structures are presented with great care and accompanied by lucid explanations. Charles Clapp, Bucknell University This textbook elegantly portrays the complementary nature of chemistry and biology. By describing biological processes in detailed chemical terms, the authors have provided a resource that provides an unparalleled look into the fascinating and emerging field of chemical biology. Hung-wen Liu, University of Texas This textbook satisfies a major need in chemistry curricula, bridging the gap between introductory organic chemistry and biochemistry/biology. It is the first book written for students that presents biological transformations from the perspective of organic mechanism. The book significantly augments modern biochemistry curricula and may catalyze a resurgence of interest in biological mechanism. Carolyn R. Bertozzi, University of California, Berkeley
About John E. McMurry
John E. McMurry received his B.A. from Harvard University and his Ph.D. at Columbia University. Dr. McMurry is a Fellow of the American Association for the Advancement of Science, and an Alfred P. Sloan Research Foundation Fellow. He has received several awards, which include the National Institutes of Health Career Development Award, the Alexander von Humboldt Senior Scientist Award, and the Max Planck Research Award. In addition to The Organic Chemistry of Biological Pathways, he is also the author of Organic Chemistry, Fundamentals of Organic Chemistry, and Chemistry (with Robert Fay). Tadhg P. Begley received his B.Sc. from National University of Ireland and his Ph.D. at the California Institute of Technology. Dr. Begley is the recipient of many awards, including the Merck Faculty Development Award and the Camille and Henry Dreyfus Teacher-Scholar Award. His research group uses the principles and techniques of organic chemistry to study complex organic transformations found in vitamin biosynthetic pathways. In addition to The Organic Chemistry of Biological Pathways, Dr. Begley has edited Cofactor Biosynthesis: A Mechanistic Perspective.
Table of contents
Foreword Preface Reviewers The Authors 1 Common Mechanisms in Biological Chemistry 2 Biomolecules 3 Lipid Metabolism 4 Carbohydrate Metabolism 5 Amino Acid Metabolism 6 Nucleotide Metabolism 7 Biosynthesis of Some Natural Products 8 A Summary of Biological Transformations Appendixes A.Visualizing Protein Structures Using the Swiss PDB Viewer B.Using the KEGG and BRENDA Databases C.Answers to End-of-Chapter Problems D. Abbreviations Used in This Book Index