Ocular Transporters in Ophthalmic Diseases and Drug Delivery

Ocular Transporters in Ophthalmic Diseases and Drug Delivery

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Description

In this exceptionally important new work, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium and nutrients across the retinal pigment epithelium.
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Product details

  • Hardback | 467 pages
  • 178 x 254 x 33.02mm | 1,003g
  • Totowa, NJ, United States
  • English
  • 2008 ed.
  • 13 Tables, black and white; XVIII, 467 p.
  • 1588299589
  • 9781588299581

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Back cover copy

This exceptionally important new work represents recent discoveries and advancements in the study of ocular transporters and their roles in ocular physiology, pathology, and drug delivery. Transporters are found on the membranes of cells and play a key role in transmitting signals between cells. In Ocular Transporters in Ophthalmic Diseases and Drug Delivery, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium, and the transport of nutrients across the retinal pigment epithelium. It also provides an in-depth look at how mutations or dysfunction of specific transporters can contribute to various disorders in the eye, including blindness, and provides readers with potential targets and strategies to allow safe passage of therapeutic drugs into the eye. Ocular Transporters in Ophthalmic Diseases and Drug Delivery is the first text book in this field and offers up-to-date information to clinicians, research scientists in academia, and the pharmaceutical industry. This work has clinical implications for drug development and therapeutic drug delivery, making it an invaluable resource for readers.
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Table of contents

Transport in the Anterior Segment
1. Aquaporins and water transport in the cornea
Verkman AS

2. Roles of Corneal Epithelial Ion Transport mechanisms in mediating responses to cytokines and osmotic stress
Reinach PS, Capo-Aponte JE, Mergler S, and Pokornny KS

3. Vitamin C Transport, Delivery, and Function in the Anterior Segment of the Eye
Kannan R, Gukasyan HJ


Transporters of the Ciliary Epithelium

4. Mechanisms of Aqueous Humor Formation: Cellular Model of aqueous inflow
Do CW, Kong CW, Chan CY, Civan MM, To CH

Lens Transporters

5. Membrane Transporters: New Roles in Lens Cataract
Donaldson PJ and Lim J

6. Lens Na+ K-ATPase
Delamere NA and Tamiya S

Transport Across the Blood Retina Barrier
7. Pathophysiology of Perictye-Containing Retinal Microvessels: Roles of Ion Channels and Transporters
Puro DG

8. Molecular mechanisms of the Inner Blood-Retinal Barrier Transporters
Tomi M and Hosoya K


Transport Across the Retinal Pigment Epithelium
9. Regulation of Transport in the RPE
Dibas A and Yorio T

10. Glucose Transporters in RPE Development
Rizzolo LJ

11. Ca2+ Channels in the RPE: Modulators of RPE Function and Communication with Neighboring Tissues
Strauss O

12. Taurine Transport Pathways in the Outer Retina in Relation to Ageing and Disease
Hussain AA and Marshall J

13. P-glycoprotein expression and Function in the Retinal pigment epithelium
Constable PA, Lawrenson JG and Abbott NJ

Transporters in the Retina

14. The Retinal Rod NCKX1 and Cone/Ganglion Cell NCKX2 Na+/Ca2+-K+ Exchangers
Schnetkamp PM, Sibukawa Y, Altimimi HF, Kinjo TG, Pratikhya P,Kang KJ, and Szerencsei RT

15. Excitatory Amino Acid Transporters in the Retina
Sarthy VP and Pow D

16. Localization and Function of GABA Transporter 1 in the retina
Casini G


Genetic Variants of Ocular Transporters: Implication in Drug Metabolism and Eye Diseases

17. Biochemical Defects Associated with Genetic Mutations in the Retina Specific ABC Transporter, ABCR, and Macular Degenerative Diseases
Biswas-Fiss EE

18. Glutamate Transporters: Retinal Disease and Regulation
Barnett NL and Bull ND

19. Glutamate Transport in Retinal Glial Cells During Diabetes
Fletcher EL and Ward MM


Ocular Drug Delivery

20. The Emerging Significance of Drug Transporters and Metabolizing Enzymes to Ophthalmic Drug Design
Attar M and Shen J

21. Barriers in Ocular Drug Delivery
Mitra AK and Gunda S

22. Ophthalmic applications of nanotechnology
Raghava S, Goel G, Kompella UB

23. Vitamin C Transporters in the Retina
Ganapathy V, Ananth S, Smith SB, Martin PM

24. The Plasma Membrane Transporters and Channels of Corneal Endothelium
Fischbarg J
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Review Text

From the reviews: "The ophthalmic structures and tissues present a series of mechanisms necessary to homeostasis maintenance, in order to enable and support the vision function. ... this book is indicated for physicians, pharmacologists, pharmacotechnicians, and investigators who wish to understand and study the complex processes of transportation and homeostasis of ocular globe, as well as to develop and formulate eye drops or apply therapies in the ophthalmology area." (Vladi Olga Consiglieri, Brazilian Journal of Pharmaceutical Sciences, 2009)
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Review quote

From the reviews:

"The ophthalmic structures and tissues present a series of mechanisms necessary to homeostasis maintenance, in order to enable and support the vision function. ... this book is indicated for physicians, pharmacologists, pharmacotechnicians, and investigators who wish to understand and study the complex processes of transportation and homeostasis of ocular globe, as well as to develop and formulate eye drops or apply therapies in the ophthalmology area." (Vladi Olga Consiglieri, Brazilian Journal of Pharmaceutical Sciences, 2009)
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About Joyce Tombran-Tink

Colin J. Barnstable, D.Phil., is Professor and Chair, Department of Neural and Behavioral Sciences
Director, Penn State Hershey Neuroscience Research Institute and Co-Director, Penn State Neuroscience Institute


Joyce Tombran-Tink, PhD, Department of Neural and Behavioral Sciences, Penn State Hershey Neuroscience Research Institute and Co-Director, Penn State Neuroscience Institute
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