Ocular Angiogenesis

Ocular Angiogenesis : Diseases, Mechanisms, and Therapeutics

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Description

Leading academic and pharmaceutical researchers and clinicians from many disciplines synthesize and summarize current clinical and basic knowledge concerning abnormal growth of blood vessels in the eye, the cause of major neovascular eye diseases. The authors also identify and assess the most promising approaches with potential for commercial exploitation and discuss the challenges encountered in developing therapeutics for ocular neovascular diseases. Highlights include illuminating chapters on gene therapy and novel drug delivery systems and excellent summaries of the newest therapeutic approaches.
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Product details

  • Hardback | 412 pages
  • 186 x 252 x 24mm | 1,138.53g
  • Totowa, NJ, United States
  • English
  • 2006 ed.
  • XVI, 412 p.
  • 1588295141
  • 9781588295149

Back cover copy

The recent intense study of pathogenic ocular angiogenesis-an abnormal growth of blood vessels in the eye responsible for the major blinding diseases throughout the world-has yielded an overwhelming flood of scientific findings, novel insights, and possible future therapeutic approaches. In Ocular Angiogenesis: Diseases, Mechanisms, and Therapeutics, leading academic and pharmaceutical researchers and clinicians from many disciplines synthesize and summarize these developments to present a comprehensive review of what is known about angiogenesis, its role in blinding diseases, and the mechanisms leading to progressive vessel dysfunction. The authors also identify and assess the most promising approaches with potential for commercial exploitation and discuss the challenges encountered in developing therapeutics for ocular neovascular diseases. Highlights include illuminating chapters on gene therapy and novel drug delivery systems and excellent summaries of the newest therapeutic approaches.
Comprehensive and multidisciplinary, Ocular Angiogenesis: Diseases, Mechanisms, and Therapeutics offers a novel view of the clinical features of pathological angiogenesis in the eye, the molecular and environmental switches that govern vessel growth, and the tremendous opportunities for and progress made in the development of new therapeutics.
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Table of contents

I. Angiogenic Diseases



Age-Related Macular Degeneration

Curtis L. Hagedorn and Ron A. Adelman



Endogenous Angiogenic Inhibitors in Diabetic Retinopathy

Jian-Xing Ma and Sarah X. Zhang



Corneal Angiogenesis

Trevor R. Carmichael



Polypoidal Choroidal Vasculopathy

Nahoko Ogata and Kanji Takahashi



Myopic Choroidal Neovascularization

Kyoko Ohno-Matsui and Takashi Tokoro



Mechanisms of the Formation and Stability of Retinal Blood Vessels

Jonathan Stone, Trent Sandercoe, and Jan Provis



Neovascular Glaucoma

James C. Tsai and M. Bruce Shields



Eales' Disease

Jyotirmay Biswas



Angiogenesis and Ocular Tumorigenesis

Nader Sheibani and Daniel M. Albert



Genetics of Ocular Vascular Disease

Jacquie Greenberg, Ari Ziskind, and Stephen P. Daiger



II. Endogenous Promoters and Inhibitors of Angiogenesis



Vascular Endothelial Growth Factor and Retinal Diseases

Sam Dahr and Karl G. Csaky



The Role of Fibroblast Growth Factors in Ocular Angiogenesis

Andreas Bikfalvi and Sophie Javerzat



Control of Neovascularization and Cell Survival in the Eye by PEDF

Joyce Tombran-Tink and Colin J. Barnstable



Thrombospondin: Guarding the Clear View

Arin Aurora and Olga V. Volpert



Regulation of Ocular Angiogenesis by Matrix Proteases and Tissue Inhibitors of Metalloproteinases

Bela Anand-Apte



Integrins in Ocular Angiogenesis

Matthew R. Ritter and Martin Friedlander



Ocular Inflammation and Neovascularization

Chi-Chao Chan and Robert B. Nussenblatt



III. Therapeutics and Delivery for Angiogenic Eye Diseases



Anti-VEGF Therapies for Diseases of the Retina and Choroid

Ming Lu and Donald J. D'Amico



Anecortave Acetate: A Novel Ocular Angiostatic Agent

Stella M. Robertson, Alberta A. Davis, David C. Dahlin, and Abbot F. Clark



Gene Therapy for Neovascular Retinopathies

Brian J. Raisler, Kenneth I. Berns, and William W. Hauswirth



Noninvasive Delivery of DNA Into the Eye

John M. Nickerson, R. Keith Shuler, Jr., John B. Davies, Phyllis K. Dioguardi, Steven M. Wolchok, Vincent T. Ciavatta, Jeffrey H. Boatright, and Henry F. Edelhauser



Novel Drug Delivery Systems for Posterior Segment Ocular Disease

Heather Sheardown and W. Mark Saltzman



Index
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Review Text

From the reviews:

"Colin J. Barnstable and co-workers have undertaken the task to present an up-to-date collection including presentations on clinical and mechanistic data as well as current therapeutic applications. The 412-page hardback book includes numerous black-and-white pictures as well as several illustrations. ... The book ... will surely find a place not only for the use of basic scientists but could be of interest for the clinician trying to understand the background on angiogenesis research." (Antonia Joussen, Graefes Archive for Clinical and Experimental Ophthalmology, Issue 246, 2008)
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Review quote

From the reviews:



"Colin J. Barnstable and co-workers have undertaken the task to present an up-to-date collection including presentations on clinical and mechanistic data as well as current therapeutic applications. The 412-page hardback book includes numerous black-and-white pictures as well as several illustrations. ... The book ... will surely find a place not only for the use of basic scientists but could be of interest for the clinician trying to understand the background on angiogenesis research." (Antonia Joussen, Graefes Archive for Clinical and Experimental Ophthalmology, Issue 246, 2008)
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