Nuclear Structure and Gene Expression

Nuclear Structure and Gene Expression

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This volume assimilates the contributions of genome organization and of the components of the nuclear matrix to the control of DNA and RNA synthesis. Consideration is given to the involvement of nuclear structure in gene localization as well as to the targeting and concentration of transcription factors. Abberrations in nuclear architecture associated with and potentially functionally related to pathologies are evaluated. Tumour cells are described from the perspective of the striking modifications in both the composition and organization of nuclear components. The text presents concepts as well as experimental approaches, which define funtionality of nuclear morphology.
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Product details

  • Hardback | 272 pages
  • 165.1 x 241.3 x 19.05mm | 635.03g
  • Academic Press Inc
  • San Diego, United States
  • English
  • b&w illustrations, colour illustrations, index, references
  • 0121001601
  • 9780121001605

Table of contents

The nuclear matrix - past and present, S. Pennman, B.J. Blencowe and J.A. Nickerson. Part 1 Nuclear matrix structure and function: mapping genomic organization and function in the cell nucleus, R. Berezney; composition and structure of the internal nuclear matrix, K.A. Mattern, R. van Driel and L. de Jong; high unwinding capability of matrix attachment regions and ATC-sequence context-specific MAR-binding proteins, T. Kohwi-Shigematsu and Y. Kohwi; the cyclin/cyclin-dependent kinase complex - regulation of cell cycle progression and nuclear disassembly, R.C. Bird. Part 2 Chromatin structure and transcription complexes: Nuclear architecture in developmental transcriptional control of cell growth and tissue-specific genes, G.S. Stein et al; transcription by RNA polymerase II and nuclear architecture, D.G. Wansink, L. de Jong and R. van Driel. Part 3 Nuclear mRNP complexes: protein disposition on nascent pre-mRNA transcripts, S.A. Amero and K.C. Sorensen.
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