Nuclear Matrix: Nuclear Matrix Nuclear Matrix - Structural and Functional Organization: v. 162, Pt. A & B Volume 162AB

Nuclear Matrix: Nuclear Matrix Nuclear Matrix - Structural and Functional Organization: v. 162, Pt. A & B Volume 162AB

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Research on the nuclear matrix has grown enormously since Bereney and Coffey first reported its isolation and initial characterization in 1974. Since then, more than 1000 papers have been published on the subject by numerous workers around the world. This is the first book devoted to reviewing the major developments in this growing field.
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Product details

  • Paperback | 1047 pages
  • 150.6 x 227.1 x 44.5mm | 1,627.3g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 012384620X
  • 9780123846204

About Ronald Berezney

Kwang Jeon received his Ph.D. in cell physiology at King's College, University of London, UK, in 1964 and taught at SUNY Buffalo and University of Tennessee. His research was concerned with the biogenesis and function of cell components in two major areas: Integration of intracellular symbionts into host cells leading to the acquisition of new cell components and cell variation; Membrane-protein recycling during endo- and exocytosis.
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Table of contents

The Nuclear Matrix: A Structural Mileu for Nuclear Genomic Function. The Architectural Organization of Nuclear Metabolism. The Structural Basis of Nuclear Function. Nuclear Domains and the Nuclear Matrix. The Nuclear Matrix and the Regulation of Chromatin Organization and Function. Contributions of Nuclear Architecture to Transcriptional Control. Chromatin Domains and Prediction of MAR Sequences. Scaffold/Matrix-Attached Regions: Structural Properties Creating Transcriptionally Active Loci. Origins of Replication and the Nuclear Matrix: The DHFR Domain as a Paradigm. The Nuclear Matrix and Virus Function. The Nuclear Matrix as a Site of Anticancer Drug Action. Nuclear Matrix Proteins as Structural and Function Components of the Mitotic Apparatus. Nuclear Matrix Isolated from Plant Cells. The Dynamic Properties and Possible Functions of Nuclear Lamins. Intracellular Structure and Nucleocytoplasmic Transport. Toward a Molecular Understanding of the Structure and Function of the Nuclear Pore Complex. Nuclear Pore Complex Proteins. Targeting and Association of Proteins with Functional Domains in the Nucleus: The Insoluble Solution. Nuclear Matrix Acceptor Binding Sites for Steroid Hormone Receptors: A Candidate Nuclear Matrix Acceptor Protein. Nuclear Matrix and the Cell Cycle. Specificity and Functional Significance of DNA Interaction with the Nuclear Matrix: New Approaches to Clarify the Old Questions. References. Subject Index.
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Review quote

Praise for the Series "Invaluable reading for all biologists." --Nature "In keeping with the high standards set by the editors...carefully prepared and edited in the customary fine format and well-illustrated style of Academic Press publications...this series is a significant contribution to a science that impinges on many fields." --The Quarterly Review of Biology "A valuable addition to any college library as current reference material for advanced undergraduates, graduate students, and professional scientists." --Choice "Maintains the tradition and set-up of the previous volumes and certainly provides up-to-date data on varied aspects of cytology...a valuable acquisition to any library." --The Nucleus
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