Nuclear Hormone Receptors

Nuclear Hormone Receptors : Molecular Mechanisms, Cellular Functions, Clinical Abnormalities

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Nuclear hormone receptors include those which recognize thyroid and steroid hormones, vitamin D and retinoic acid. Together they form a supergene family characterized by their ability to bind both ligands and the genes which respond to those ligands. "Nuclear Hormone Receptors" an overview of this supergene family and contains up-to-date accounts of the structure of these receptors and the genes which encode them. It also covers their interaction with DNA recognition sites, chromatin and transcription factors, the mechanisms by which they regulate gene expression during cell growth, development and differentiation, and defective receptors involved in endocrine-related including cancer.
The book is illustrated and fully referenced and cross indexed and is intended to be of use to molecular biologists (offering them detailed descriptions of the best characterized mediators of eukaryotic gene regulation), endocrinologists (offering them an explanation of the mechanisms by which hormones mediate cellular responses), pharmacologists (who are presented with the biochemical action of hormones) and clinicians, for whom the importance of these receptors in deficiences and cancer is demonstrated.
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Product details

  • Hardback | 424 pages
  • 156 x 230 x 26mm | 759.99g
  • Academic Press Inc
  • San Diego, United States
  • index, references, illustrations
  • 0125450729
  • 9780125450720

Table of contents

Overview of the nuclear receptor family, E.V.Jensen; the oestrogen receptor - from perception to mechanism, S.Green and P.Chambom; the gluticocorticoid receptor, M.Danielson; nuclear thyroid hormone receptors, W.W.Chin; the steroid receptor superfamily transactivators of gene expression, S.Y.Tsai et al; hormone response elements, E.Martinez and W. Wahli; co-operative trans-activation of steroid receptors, M.Nukker et al; repression of gene expression by steroid and thyroid hormones, I.E. Akerbolm; characterization of DNA receptor interactions, M. Beato et al; the interaction of steroid receptors with chromatin, G.L.Hager et al; ontogeny of sex steroids in mammals, G.R.Cunha et al; retinoic acid receptors and vertebrate limb morphogenesis, C.W.Ragsdale and J.P. Brockes; the role of steroid hormones and growth factors in the control of normal and malignant growth, R.Clarke et al; genetic defects of receptors involved in disease, M.R.Hughes and B.W.O'Malley.
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