Nitric Oxide

Nitric Oxide : Biology and Pathobiology

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Nitric Oxide: Biology and Pathobiology, Third Edition, provides information on nitric oxide, a signaling molecule of key importance for the cardiovascular system that regulates blood pressure and blood flow to different organs.

With recent links to the role of nitric oxide in the expression of healthy benefits of controlled diet and aerobic exercise, and the reactions of nitric oxide that can impact cell signaling, this book provides a comprehensive resource during a time when increased research attention is being paid across the fields of pharmacology, biochemistry, cell and molecular biology, chemistry, immunology, neurobiology, immunology, nutrition sciences, drug development and the clinical management of both acute and chronic diseases.
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Product details

  • Hardback | 434 pages
  • 216 x 276 x 25.4mm | 1,380g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 3rd edition
  • 0128042737
  • 9780128042731

Table of contents

Introduction and Overview


1. A concise history of the discovery of mammalian nitric oxide (nitrogen monoxide) biogenesis

Chemical Biology

2. An integrated view of the chemical biology of NO, CO, H2S and O2

3. Detection of nitric oxide and related species in biological systems: A state-of-the-art review

4. S-nitrosothiols and nitric oxide biology and therapeutics

5. Cooperative interactions between NO and H2S: Chemistry, biology, physiology, pathophysiology

6. Heme protein metabolism of NO and nitrite


7. Cross-regulation between iNOS/NO and Wnt/ss-catenin signaling pathways

8. Regulation and physiological functions of NO-sensitive guanylyl cyclase

9. Upcoupling eNOS in cardiovascular disease


10. Synthesis, actions and perspectives of nitric oxide in photosynthetic organisms

11. Mitochondria and nitric oxide

12. Nitric oxide formation from inorganic nitrate

13. Biochemistry of molybdopterin nitrate/nitrite reductases

14. NOS, NO and the red cell

15. Update on nitrite reduction in ischaemic disease: Mechanisms and clinical translation

16. Electrophilic Nitro-Fatty Acids: Nitric Oxide and Nitrite-Derived Signaling Mediators and New Drug Candidates

17. Regulation of redox signaling by a nitrated nucleotide and reactive cysteine persulfides

18. Diffusional control of nitric oxide in the vessel wall

19. Asymmetric-Dimethylarginine

20. The role of nitric oxide in epigenetic regulation

Inflammation and Pathobiology

21. Peroxynitrite formation and detection in living cells

22. Nitric oxide in sepsis and hemorrhagic shock: Beneficial or detrimental?

23. NO signaling defects in hypertension

24. Nitric oxide regulation of cardiovascular physiology and pathophysiology

25. Inhaled nitric oxide: Current clinical use and future potential uses and development

26. The defective arginine-nitric oxide pathway in sickle cell disease

27. Aberrant nitric oxide signaling contributes to protein misfolding in neurodegenerative diseases via S-nitrosylation and tyrosine nitration

28. NO in cancer: Carcinogenesis, metastases and therapy
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About Louis J. Ignarro

Louis J Ignarro is the Recipient of the 1998 Nobel Prize in Physiology or Medicine for demonstrating the signaling properties of nitric oxide. He is presently a Professor Emeritus at the Centre for Health Sciences, UCLA. His various other accolades include the 1998 Basic Research Price of the American Heart Association membership of the National Academy of Sciences, membership of the American Academy of Arts and Sciences, American Heart Association Distinguished Scientist, 2008, founder of the Nitric Oxide Society, founder and Editor-in-Chief of Nitric Oxide Biology and Chemistry, and notoriously the 'Father of Viagra'. Bruce Freeman is a distinguished figure in the field of biochemistry. He received his PhD from University of California, Riverside, in 1978. He has since gone on to found and act as a scientific advisor for Complexa Inc and Nitromega Inc. Professor Freeman has conducted extensive research in the diefld of drug discovery, redox pharmacology, signal transduction and metabolic syndrome pharmacology. He currently holds the Irwin Fridovich Professor and Chair position at the University of Pittsburgh.
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