Nitric Oxide Donors

Nitric Oxide Donors : For Pharmaceutical and Biological Applications

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Nitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric oxide donors, from organic nitrates to nitroso compounds, guanidines and metal-NO complexes. In addition to a detailed treatment of the chemistry of NO donors, numerous examples of successful diagnostic and pharmacological applications are discussed, as well as further therapeutic targets for these substances.
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Product details

  • Hardback | 407 pages
  • 186 x 246 x 25.4mm | 918g
  • Weinheim, Germany
  • English
  • 3527310150
  • 9783527310159

Back cover copy

Nitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric oxide donors, from organic nitrates to nitroso compounds, guanidines and metal-NO complexes.
In addition to a detailed treatment of the chemistry of NO donors, numerous examples of successful diagnostic and pharmacological applications are discussed, as well as further therapeutic targets for these substances.
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Table of contents

Part 1: Chemistry of NO Donors.1 NO and NO Donors (Tingwei Bill Cai, Peng George Wang, and Alvin A. Holder).2 Organic Nitrates and Nitrites (Roger Harrison).3 N-Nitroso Compounds (Arindam Talukdar, Peng George Wang).4 The Role of S-Nitrosothiols in the Biological Milieu (Bulent Mutus).5 Metal-NO complexes: Structures, Syntheses, Properties and NO-releasing Mechanisms (Tara P. Dasgupta, Danielle V. Aquart).6 The NO-releasing Heterocycles (Alberto Gasco, Karl Schoenafinger).7 C-Nitroso Compounds, Oximes, N-Hydroxyguanidines and N-Hydroxyureas (S. Bruce King).Part 2: NO Donors' Applications in Biological Research.8 Vasodilators for Biological Research (Anthony Robert Butler, Russell James Pearson).9 NO Donors as Antiplatelet Agents (Anna Kobsar, Martin Eigenthaler).10 Control of NO Production (Noriko Fujiwara, Keiichiro Suzuki, Naoyuki Taniguchi).Part 3: Clinical Applications of NO Donors.11 Nitric Oxide Donors in Cardiovascular Disease (Martin Feelisch, Joseph Loscalzo).12 Nitric Oxide Donors as Anti-platelet Agents for Thromboembolic Disorders: Clinical Status and Therapeutic Prognosis (David R. Janero, David S. Garvey).13 NO and Gene Regulation (Jie Zhou, Bernhard Brune).14 Nitric Oxide and Central Nervous System Diseases (Elizabeth Mazzio, Karam F. A. Soliman).Index.
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Review quote

"This collection of review articles provides a thorough overview of the chemistry, biochemistry, and pharmacology of nitric oxide donors." (E-STREAMS, April 2006)
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About Peng George Wang

Peng George Wang obtained his B.S. degree in Chemistry from Nankai University, China in 1984 and his Ph.D. degree in organic chemistry from the University of California, Berkeley in 1990. He then conducted postdoctoral research at the Scripps Research Institute and in 1994 became an Assistant Professor at the University of Miami. From 1997 to 2003, he was a faculty member of Wayne State University. In 2003, he took his current position in the Departments of Biochemistry and Chemistry as Ohio Eminent Scholar in Macromolecular Structure and Function at the Ohio State University. In 2002, Professor Wang has won the Isbell Award from the Divison of Carbohydrate Chemistry of the American Chemical Society. Tingwei Bill Cai is a research assistant in Professor P. G. Wang's group at The Ohio State University. He studied chemistry at Peking University in China, where he completed his BS and MS degree in Medicinal Chemistry. Then he worked in National Institutes of Pharmaceutical Research & Development as a research scientist. In 2000, he joined Professor Wang's group. His main research focuses on drug design and synthesis. His research field covered carbohydrate, nucleic acid, heterocyclic and nitric oxide chemistry. He has published more than ten scientific papers. He is a member of American Chemical Society. Naoyuki Taniguchi graduated from the Hokkaido University School of Medicine, followed by an M.D. degree in 1967, and completed the doctoral course of medicine at the Graduate School of Hokkaido University and obtained a Ph.D in 1972. He was then appointed assistant professor at the Hokkaido University School of Medicine in 1975 and was a visiting professor in the group of Dr. Alton Meister at Cornell University Medical College between 1976 and 1977. Returning to Hokkaido University, he joined the Biochemistry Laboratory at the Cancer Institute, before being appointed as a full professor at the Department of Biochemistry, Osaka University Medical School in 1986. Professor Taniguchi is an honorary member of the American Society for Biochemistry and Molecular Biology and has received numerous awards, among them the International Glycoconjugate Organization (IGO) Award in 2001.
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