Neuroprotection Methods and Protocols
28%
off

Neuroprotection Methods and Protocols

Edited by 

Free delivery worldwide

Available. Dispatched from the UK in 3 business days
When will my order arrive?

Description

This book examines current research into the role of neuronal death in cell signaling pathways, and its role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. After introducing neurodegenerative, traumatic, and ishemic disorders, the authors cover in vitro and animal systems, and cellular and molecular mechanisms.show more

Product details

  • Hardback | 239 pages
  • 158 x 230 x 18mm | 557.92g
  • Humana Press Inc.
  • Totowa, NJ, United States
  • English
  • Illustrated
  • Illustrated
  • 45 black & white illustrations, 3 colour illustrations, 6 black & white tables, biography
  • 1588296660
  • 9781588296665

Review quote

From the reviews: "Research in neuroprotection is essential for the development of therapies for stroke and neurodegenerative diseases. This book reviews research methods currently used for prevention and slowing of central nervous system degenerative disorders. ... Neurologists, neurosurgeons, and neuroscientists interested in research in neuroprotection are the main audience for this book. This is a comprehensive approach to research in neuroprotection. ... the book is well written and structured with no drawbacks. ... a good book for neuroscience and neurological libraries." (Celso Agner, Doody's Review Service, December, 2007)show more

Back cover copy

Due to an aging population, the incidence of age-related neurodegenerative diseases is expected to rise dramatically. In Neuroprotection Methods and Protocols, a team of skilled, renowned researchers provide step-by-step laboratory protocols intended to slow or prevent the progression of such diseases. Focusing on neuroprotective approaches, this volume describes basic scientific discoveries and the application of such research within different laboratories in a clear and systematic way in order to orient scientists in this complicated field. The chapters follow the Methods in Molecular Biology series format, consisting of readily reproducible methods, lists of the necessary materials, and a Notes section which aids the researcher in solving and avoiding technical problems. Comprehensive and easy to use, Neuroprotection Methods and Protocols is the perfect reference for basic neuroscientists hoping to move forward the ever-important field of neuroprotection and neuronal death research. "show more

Table of contents

TABLE OF CONTENTS 1) Neuronal death and neuroprotection (REVIEW CHAPTER) Mariaelena Repici, Jean Mariani and Tiziana Borsello 2) The use of propidium iodide to assess excitotoxic neuronal death in primary mixed cortical cultures. Anthony C Lau, Hong Cui, Michael Tymianski 3) A modified silver technique (De Olmos Stain) for assessment of neuronal and axonal degeneration. Tatyana I. Tenkova and Mark P. Goldberg 4) Model of acute injury to study neuroprotection. Michal Schwartz and Jonathan Kipnis 5) Organotypic entorhino-hippocampal slice cultures - a tool to study the molecular and cellular regulation of axonal regeneration and collateral sprouting in vitro. Domenico Del Turco and Thomas Deller 6) Role of Nrf2-dependent ARE-driven antioxidant pathway in neuroprotection. Jiang Li, Marcus J. Calkins, Delinda A. Johnson, Jeffrey A. Johnson 7) Biochemical methods to assess the coupling of brain energy metabolism in control and disease states. Jennifer Zechel, David W. Lust, Michele Puchowicz 8) A Method for Isolating Prosurvival Targets of NF-=B/Rel Transcription Factors. Francesca Zazzeroni, Christian Kuntzen, Can G. Pham, Salvatore Papa, Concetta Bubici, James R. Knabb, and Guido Franzoso 9) Functional cloning of genes regulating apoptosis in neuronal cells. Roberta Visconti and Luciano D'Adamio 10) Characterization of mRNA Expression in Single Neurons. David M. Lin, Brandon Loveall, John Ewer, David L. Deitcher, and Nikolaus J. Sucher 11) Brain on a chip: a method to detect novel neuroprotective candidate targets. Yang Tang and Myriam Bernaudin 12) Intracerebral infusion of neurotrophic factors. Theo Hagg 13) Synthesis of Cell Penetrating Peptides and Their Application in Neurobiology. Gunnar P.H. Dietz and Mathias Bahr 14) The stem cells as a potential treatment for neurodegeneration. DanielaFerrari, Angelo Luigi Vescovi, Daniele Bottai 15) In Vivo Tomographic Neuroimaging Studies of Neurodegeneration and Neuroprotection (REVIEW CHAPTER) Rikki N. Waterhouse and Jun Zhaoshow more

Review Text

From the reviews: "Research in neuroprotection is essential for the development of therapies for stroke and neurodegenerative diseases. This book reviews research methods currently used for prevention and slowing of central nervous system degenerative disorders. ... Neurologists, neurosurgeons, and neuroscientists interested in research in neuroprotection are the main audience for this book. This is a comprehensive approach to research in neuroprotection. ... the book is well written and structured with no drawbacks. ... a good book for neuroscience and neurological libraries." (Celso Agner, Doody's Review Service, December, 2007)show more