The Neuron

The Neuron : Cell and Molecular Biology

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Description

The third edition of "The Neuron" provides a comprehensive first course in the cell and molecular biology of nerve cells. The first part of the book covers the properties of the many newly discovered ion channels that have emerged through mapping of the genome. These channels shape the way a single neuron generates varied patterns of electrical activity. Next are covered the molecular mechanisms that convert electrical activity into the secretion of neurotransmitter and hormones at synaptic junctions between neurons. The second part of the book covers the biochemical pathways that are linked to the action of neurotransmitters and that can alter the cellular properties of neurons or sensory cells that transduce information from the outside world into the electrical code used by neurons. The final section reviews our rapidly expanding knowledge of the molecular factors that induce an undifferentiated cell to become a neuron, and then guide it to form appropriate synaptic connections with its partners. This section also focuses on the role of ongoing experience and activity in shaping these connections, and finishes with an account of mechanisms thought to underlie the phenomena of learning and memory. This book includes: a thoroughly revised and expanded edition (60 pages longer) and features a new 8-page , 4-color insert as well as the following changes: the mapping of the human genome and that of other species has led to the discovery of numerous new proteins that regulate the excitability, development, and function of neurons. These have been incorporated into the new edition in nearly all of the chapters; the first section of the book, which deals with neuronal excitability, has been reorganized to make it more readable for those students with less background in physical sciences. The changes also include: a new chapter has been added to this section to allow the incorporation of new information on ion channel structure and on the role of channel auxiliary proteins in modulating neuronal excitability; a new chapter, "The Birth and Death of Neurons," has been added to the last section. In addition to covering new discoveries about the early development of neurons, this chapter describes the recent discovery that new neurons are continually being formed in certain parts of the adult mammalian brain. It also describes research on stem cells, which holds therapeutic potential for the repair of damaged or diseased brain tissue; the use of imaging technologies in the study of the brain has expanded enormously in the past few years. The new edition describes some of these new approaches. Moreover, the introduction of full color plates now allows many new images to be presented in their original form.show more

Product details

  • Hardback | 626 pages
  • 165.1 x 236.2 x 40.6mm | 1,292.75g
  • Oxford University Press Inc
  • New York, United States
  • English
  • Revised
  • 3rd Revised edition
  • 8pp colour plates, numerous half tone and line illustrations
  • 0195145224
  • 9780195145229

Review quote

Praise from the Previous Edition "The format of each chapter is ideally suited for easy, enjoyable and almost effortless learning.... In summary, this is a superbly written and well-illustrated text covering all the major aspects of neuroscientific knowledge.... Regardless of the state of knowledge or the specific expertise of the reader, every neuroscientist should keep a copy handy." -- Journal of Psychiatry and Neuroscience"Overall I consider this to be an outstanding, easily readable, and quite up-to-date overview of fundamental neurobiology. This book is quite useful for the clinician who wishes to have a digestible presentation of basic neuroscience as a prelude to understanding neurological disease." --Canadian Journal of Neurological Sciences"The format of each chapter is ideally suited for easy, enjoyable and almost effortless learning.... In summary, this is a superbly written and well-illustrated text covering all the major aspects of neuroscientific knowledge.... Regardless of the state of knowledge or the specific expertise of the reader, every neuroscientist should keep a copy handy." -- Journal of Psychiatry and Neuroscience"Overall I consider this to be an outstanding, easily readable, and quite up-to-date overview of fundamental neurobiology. This book is quite useful for the clinician who wishes to have a digestible presentation of basic neuroscience as a prelude to understanding neurological disease." --Canadian Journal of Neurological SciencesPraise for Third Edition "In spite of the overwhelming amount of information on all things neuronal, the authors have succeeded in providing in-depth coverage on many new discoveries in neuroscience and integrating the material into a readable text. ... The Neuron promises to be a very useful textbook ... and a helpful introductory guide for scientists just becoming interested in the nervous system."--The Quarterly Review of Biologyshow more

Table of contents

I. INTRODUCTION; 1. Signaling in the Brain; 2. Form and Function in Cells of the Brain; II. ELECTRICAL PROPERTIES OF NEURONS; 3. Electrical Signaling in Neurons; 4. Membrane Ion Channels and Ion Currents; 5. Ion Channels are Membrane Proteins; 6. Ion Channels, Membrane Ion Currents, and the Action Potential; 7. Diversity in the Structure and Function of Ion Channels; III. INTERCELLULAR COMMUNICATION; 8. How Neurons Communicate: Gap Junctions and Neurosecretion; 9. Synaptic Release of Neurotransmitters; 10. Neurotransmitters and Neurohormones; 11. Receptors and Transduction Mechanisms I: Receptors Couples Directly to Ion Channels; 12. Receptors and Transduction Mechanisms II: Indirectly Coupled Receptor/Ion Channel Systems; 13. Neuromodulation: Mechanisms of Induced Changes in the Electrical Behavior of Nerve Cells; 14. Sensory Receptors; IV. BEHAVIOR AND PLASTICITY; 15. The Birth and Death of a Neuron; 16. Neuronal Growth and Trophic Factors; 17. Adhesion Molecules and Axon Pathfinding; 18. Formation, Maintenance, and Plasticity; 19. Neural Networks and Behavior; 20. Learning and Memoryshow more

Rating details

28 ratings
4.39 out of 5 stars
5 57% (16)
4 32% (9)
3 7% (2)
2 0% (0)
1 4% (1)
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