Neuromodulation : The Biochemical Control of Neuronal Excitability

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This volume provides an introduction to the general principles of neuromodulation-the key neurobiological process for understanding how the brain works. Emphasizing ion channels and biochemical mechanisms of protein phosphorylation, the book shows how neurons regulate their intracellular calcium concentration by modulating the activity of certain ion channels. It goes on to explain the function of intracellular calcium and describes some fascinating neuromodulatory phenomena in the mammalian brain that have long awaited the kind of mechanistic investigations possible in simpler systems. Bridging the gap between neurochemistry and neurophysiology, the authors make complex concepts and research approaches comprehensible to scientists in either field.
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Product details

  • Hardback | 298 pages
  • 154.9 x 238.8 x 20.3mm | 589.68g
  • New York, United States
  • English
  • 019504097X
  • 9780195040975
  • 2,125,691

Table of contents

1. What is Neuromodulation? ; 2. Ion Currents and Ion Channels, Substrates for Neuromodulation ; 3. Mechanisms and Modulation of Ion Channel Proteins ; 4. Biochemical Mechanisms in the Modulation of Ion Channel Function ; 5. Phosphorylation of Purified Ion Channel Proteins ; 6. Modulation of the Endogenous Rhythmic Bursting Activity in the Aplysia Neuron R15 ; 7. Modulation of Voltage-Dependent Potassium Currents During Long-Lasting Changes in Neuronal Activity ; 8. Modulation of Ion Channels Which are Regulated by Calcium ; 9. Modulation of Potassium Currents of Vertebrate Neurons ; 10. Modulation of a Potassium Channel in Aplysia Ssensory Neurons by Cyclic AMP-dependent Protein Phosphorylation ; 11. Modulation of Calcium Currents in Heart Cells and Neurons ; 12. Neurotransmitter Release and Its Modulation ; 13. Neuromodulation in the Mammalian Brain: The New Frontier
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Review quote

The first chapter of [this book] is devoted to a definition and description of what is meant by the term neuromodulation: "The ability of neurons to alter their electrical properties in response to intracellular changes resulting from synaptic or hormonal stimulation." In the opinion of the reviewer this is a very good restriction, as it appears that this field of cellular neurobiology shows exciting developments....A very good book for general neurobiologists to
get quickly acquainted with the newly emerging insights into the mechanisms which neurons use, to change their excitability level. In addition it provides the specialist with an opportunity to broaden his outlook in the field of neurobiology. * Journal of the Neurological Sciences * An absolutely first class treatise...Can be warmly recommended to graduate students in the neurosciences for its clarity and lucidity. * Quarterly Review of Biology * The authors focus on the best-understood mechanisms of electrical modulation, namely those in which the properties of membrane ion channels are modified by second messenger systems...While only a decade or so ago the brain was considered too complicated to be studied effectively at the molecular level, the biochemical basis of neuromodulation in the mammalian brain now stands at the frontier of research...This volume provides an effective introduction to the study of
neuromodulation and is appropriate as a text for graduate courses. * Cell * Useful not only to the novice but to virtually any investigator interested in cellular neurobiology. It certainly should be examined by individuals who teach neuroscience-related courses. * Science * Should be of interest to neuroscientists, biochemists, biophysicists, physiologists, and to graduate students in these fields. * Biological Abstracts/RRM (R) *
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