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Reflecting the dramatic advances in the field since the first edition was published 10 years ago, this book is the only comprehensive reference on glial cells. The majority of neuroscientists now acknowledge that neuroglia are elemental to most, if not all, brain functions. The second edition covers the entire field of glial research from the basic molecular and cellular structure of these cells to their involvement in neurological diseases including stroke, Alzheimer's disease and multiple sclerosis. It includes new chapters on transmitter release by exocytosis from glia, glia derived stem cells, glia and synaptic transmission, glia and axon guidance, mechanisms of glial injury, and the roles of glia in different diseases. The new edition was written with both students and experts in mind. It provides a basic introduction to the entire range of glial topics and detailed information with critical assessment of the research literature. Neuroscience textbooks focus on the properties of neurons, whereas this book fills the information void about the brain's other cells. This book is an essential reference source for newcomers, including graduate students, to neuroanatomy, neurochemistry, neurophysiology and molecular neurobiology. It is also a vital companion for established researchers in these fields as well as clinicians in neurology, neurosurgery, psychiatry, neuropathology and more

Product details

  • Hardback | 624 pages
  • 224 x 284 x 40mm | 2,140.98g
  • Oxford University Press Inc
  • New York, United States
  • English
  • Revised
  • 2nd Revised edition
  • numerous black & white photographs and line illlustrations
  • 0195152220
  • 9780195152227
  • 2,044,274

Review quote

The book is unquestionably an authoritative and comprehensive compilation of the various aspects on neuroglia. Journal of Chemical Neuroanatomy, Vol 31 ... I very much like this new edition of Neuroglia. it is a wonderful book focused entirely on glial cells ... [it is] without doubt the best place to turn to for some glial education ... All in all, Kettenmann and Ransom have once again done a great job of putting together this terrific book ... Nature Neuroscienceshow more

Table of contents

1. The Concept of neuroglia: a historical perspective; PART 1: PROPERTIES OF NEUROGLIAL CELLS; Morphology and ultrastructure of glial cells; 2. Astrocytes and ependymal glia; 3. Structure and function of oligodentrocytes; 4. Schwann cells and myelin; 5. Microglial cells; Lineage; 6. Lineages of astrocytes and oligodendrocytes; 7. The Schwann cell lineage; 8. The role of neurogenic astroglial cells in the developing and adult central nervous system; Physiological and biochemical properties; 9. Voltage-activated ion channels in glial cells; 10. Receptors for neurotransmitters and hormones; 11. Cytokine and chemokine receptors and signalling; 12. Mechanisms of solute transport in glia; 13. Gap junctions and hemichannels; 14. Quantal release of transmitter: not only from neurons but from astrocytes as well?; 15. Enzymes of carbohydrate and energy metabolism; 16. Second messenger systems; 17. Intracellular calcium control mechanisms in glia; 18. Cytoskeletal proteins in astroglia; PART 2: FUNCTIONS OF NEUROGLIAL CELLS; Myelin; 19. Molecular biology of myelination; 20. Factors controlling myelin formation; 21. Myelin function and saltatory conduction; Immune function; 22. Cytokine production; 23. Interaction of glial cells with monocytes; 24. Antigen processing, presentation, and T cell interaction; Blood-brain-barrier; 25. The role of glia in the formation and function of the blood-brain-barrier; Influence on neurons; 26. Extracellular potassium and pH: homeostasis and signalling; 27. Astrocyte neurotransmitter uptake; 28. Glia and synaptic transmission; 29. The central role of astrocytes in neuroenergetics; 30. Growth factors for neurons provided by macroglial cells; Development; 31. Radial glial cells: scaffolding for cortical development and evolution; 32. Axon guidance; PART 3: DISEASE AND NEUROGLIAL CELLS; Mechanisms of glial injury; 33. Astrocyte injury; 34. Oligodendrocyte and Schwann cell injury; 35. Response of microglia to brain injury; Recovery of neural function; 36. Axonal regeneration in the peripheral nervous system of mammals; 37. Axonal regeneration in the central nervous system of mammals; 38. Transplantation of myelin-forming cells; Diseases; 39. Multiple Sclerosis; 40. Human immunodeficiency virus infection of the central nervous system; 41. Focal cerebral ischemia: the multifaceted role of glial cells; 42. Gliomas; 43. Neurological mouse mutants: a molecular-genetic analysis of myelin proteins; 44. Astrocytic swelling in neuropathology; 45. The activation of microglia as an early sign of disease progression in Alzheimer's disease; 46. Peripheral neuropathy and the Schwann cell; 47. Reaction of glial cells in infectious disorders of the central nervous systemshow more

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