Neurobiology of Mental Illness

Neurobiology of Mental Illness

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The new edition of this definitive textbook reflects the continuing reintegration of psychiatry into the mainstream of biomedical science. The research tools that are transforming other branches of medicine - epidemiology, genetics, molecular biology, imaging, and medicinal chemistry - are also transforming psychiatry. The field stands poised to make dramatic advances in defining disease pathogenesis, developing diagnostic methods capable of identifying specific and valid disease entities, discovering novel and more effective treatments, and ultimately preventing psychiatric disorders. The Neurobiology of Mental Illness is written by world-renowned experts in basic neuroscience and the pathophysiology and treatment of psychiatric disorders. It begins with a succinct overview of the basic neurosciences followed by and evaluation of the tools that are available for the study of mental disorders in humans. The core of the book is a series of consistently organized sections on the major psychiatric disorders that cover their diagnostic classification, molecular genetics, functional neuroanatomy, neurochemistry and pharmacology, neuroimaging, and principles of pharmacotherapy. Chapters are written in a clear style that is easily accessible to practising psychiatrists, and yet they are detailed enough to interest researchers and academics. For this second edition, every section has been thoroughly updated, and 13 new chapters have been added in areas where significant advances have been made, including functional genomics and animal models of illness; epidemiology; cognitive neuroscience; postmortem investigation of human brain; drug discovery methods for psychiatric disorders; the neurobiology of schizophrenia; animal models of anxiety disorders; neuroimaging studies of anxiety disorders; developmental neurobiology and childhood onset of psychiatric disorders; the neurobiology of mental retardation; the interface between neurological and psychiatric disorders; the neurobiology of circadian rhythms; and the neurobiology of sleep disorders. Both as a textbook and a reference work, Neurobiology of Mental Illness represents a uniquely valuable resource for psychiatrists, neuroscientists, and their students or trainees.show more

Product details

  • Hardback | 1250 pages
  • 214 x 280 x 54mm | 3,138.89g
  • Oxford University Press Inc
  • New York, United States
  • English
  • 2nd Revised edition
  • 16pp colour plates, numerous line drawings and tables
  • 0195149629
  • 9780195149623

Table of contents

PART I BASIC NEUROBIOLOGY - SECTION EDITOR: ERIC J. NESTLER; 1. Overview of Brain Development; 2. Neurochemical Systems in the Central Nervous System; 3. Using Basic Electrophysiology to Understand the Neurobiology of Mental Illness; 4. Principles of Signal Transduction; 5. Mechanisms of Neural Plasticity; 6. Principles of Molecular Biology; 7. Functional Genomics and Models of Mental Illness; PART II METHODS OF CLINICAL NEUROBIOLOGICAL RESEARCH - SECTION EDITOR: ROBERT B. INNIS; 8. Contributions of Epidemiology to the Neurobiology of Mental Illness; 9. Basic Methods for Clinical Molecular Genetics of Psychiatric Illness; 10. Methods of Affective Clinical Psychophysiology; 11. Clinical Neurochemistry; 12. Clinical Neuroendocrinology; 13. Neuroimmunology; 14. Cognitive Neuroscience Bridging Thinking and Feeling to the Brain, and its Implications for Psychiatry; 15. Neuroimaging Methodologies: Utilizing Radiotracers or Nuclear Magnetic Resonance; 16. Methods of Postmortem Investigation of Human Brain; 17. Drug Discovery and Development Methods for Mental Illness; PART III PSYCHOSES - SECTION EDITOR: DANIEL WEINBERGER; 18. Diagnostic Classification of the Psychoses: Historical Context and Implications for Neurobiology; 19. Molecular Genetics of Schizophrenia; 20. Animal Models of Psychoses; 21. Pharmacologic Models of Psychoses; 22. The Neurobiology of Schizophrenia; 23. Functional Brain Imaging Studies in Schizophrenia; 24. Psychophysiological and Information Processing Approaches to Schizophrenia; 25. Principles of the Pharmacotherapy of Schizophrenia; PART IV MOOD DISORDERS - SECTION EDITOR: CHARLES B. NEMEROFF; 26. Diagnostic Classification of Mood Disorders: Historical Context and Implications for Neurobiology; 27. Linkage and Association Studies of Bipolar Disorders; 28. Animal Models of Mood Disorders; 29. The Cellular Neurobiology of Bipolar Disorder; 30. Neurochemical Theories of Depression I: Preclinical Studies; 31. The Neurochemistry of Depressive Disorders: Clinical Studies; 32. The Neurobiological Foundation of Mental Illness; 33. Principles of Pharmacotherapy of Depression; 34. Abnormalities of Brain Structure and Function in Mood Disorders Based Upon Postmortem Investigation; PART V ANXIETY DISORDERS - SECTION EDITOR: DENNIS S. CHARNEY; 35. Diagnostic Classification of Anxiety Disorders: DSM-IV and Beyond; 36. Molecular Genetics of Anxiety; 37. Animal Models of Anxiety Disorders; 38. Structural and Functional Plasticity in the Hippocampal Formation: Stress, Adaptation and Disease; 39. Functional Neuroanatomy of Anxiety and Fear; 40. The Neurobiology of Anxiety Disorders; 41. The Neurobiology and Treatment of Obsessive-Compulsive Disorder; 42. Neuroimaging Studies of Anxiety Disorders; 43. Principles of the Pharmacotherapy of Anxiety Disorders; PART IV SUBSTANCE ABUSE DISORDERS - SECTION EDITOR: STEVEN E. HYMAN; 44. Animal Models of Addiction; 45. Cellular and Molecular Mechanisms of Addiction; 46. Genetic Epidemiology of Substance Ashow more

Review quote

"The second edition of Neurobiology of Mental Illness...stands as a superb contribution to the understanding of neurobiological bases of mental disorders. It is a highly readable, well-organized text. Anyone interested in the neurobiological underpinnings of psychiatric conditions would be well served to have this text on hand, both for casual browsing and for in-depth study." --The Journal of Nervous and Mental Disease"The chapters are clearly and consistently written and attractively presented. This volume embodies a thoroughgoing materialism." -Cognitive NeuropsychiatryPraise for the First Edition: "Neurobiology of Mental Illness bridges the gap between the science and art of psychiatric medical practice and allows clinicians and researchers to see into each other's worlds." --JAMA." . . well-written, neatly organized, and synthetic . . . a text of this sort is a requisite for any modern psychiatry residency curriculum . . . Neurobiology of Mental Illness bridges the gap between the science and art of psychiatric medical practice and allows clinicians and researchers to see into each other's worlds."--Steven J. Siegel, MD, PhD, in JAMA"The authors are uniformly first rate...The discipline described here is a far cry from the psychiatry we grew up with. Sigmund Freud, a neurobiologist by training, would have been proud."--J.L. Numberger Jr., in The New England Journal of Medicine"The editors deserve tremendous credit for compiling a most useful reference text, and I am not aware of a similar textbook that is anywhere as comprehensive, up-to-date, or focused on the basic science of our field. I think this book would be an excellent resource for psychiatric residents, early doctoral students in neurochemistry and the neurosciences, and psychiatric researchers interested in the basic underpinnings of mental disorders."--David L. Dunner in The American Journal of Psychiatry..".an excellent book, well written and well edited...and packed with information. I found it thought-provoking and intensely educational."--Tim Betts in Brain"The book provides a well-written, neatly organized, and synthetic middle ground between a more comprehensive text of clinical psychiatry, as provided in Synopsis of Psychiatry...and basic neuroscience texts, such as Principles of Neuroscience..." JAMA..".the best account to date of the neurobiology of mental disorders. It is an excellent source of reference but many of the chapters provide very good conceptual overviews that well deserve to be read as introductions to the field. A book to dip into for pleasure, as well as one to turn to in order to find out what is known on a particular topic."--Sir Michael Rutter in Trends in Neuroscienceshow more

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