Neurobiology of Brain Disorders

Neurobiology of Brain Disorders : Biological Basis of Neurological and Psychiatric Disorders

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Neurobiology of Brain Disorders is the first book directed primarily at basic scientists to offer a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular, and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in the diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases, and to discern connections between basic research and these relevant clinical conditions.

This book addresses developmental, autoimmune, central, and peripheral neurodegeneration; infectious diseases; and diseases of higher function. The final chapters deal with broader issues, including some of the ethical concerns raised by neuroscience and a discussion of health disparities. Included in each chapter is coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. Written and edited by a diverse team of international experts, Neurobiology of Brain Disorders is essential reading for anyone wishing to explore the basic science underlying neurological and neuropsychiatric diseases.
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Product details

  • Hardback | 824 pages
  • 226 x 276 x 42mm | 2,519.96g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0123982707
  • 9780123982704
  • 1,082,619

Table of contents

1. An Introduction: A Clinical Neuroscientist and Disorders of the Brain Section I: Developmental Disorders 2. Introduction 3. Developmental Disabilities and Metabolic Disorders 4. Attention-Deficit/Hyperactivity Disorder 5. Down Syndrome: A Model for Chromosome Abnormalities 6. Autism Spectrum Disorder 7. Rett Syndrome: From the Involved Genes to Treatment 8. Fragile X-associated Disorders Section II: Diseases of the Peripheral Nervous System 9. Introduction 10. Myasthenia Gravis 11. Muscular Dystrophy 12. Peripheral Neuropathies and Guillain-Barre Syndrome 13. Diabetes and Its Consequences Section III: Diseases of the Central Nervous System and Neurodegeneration 14. Introduction 15. Spinal Cord Injury 16. Traumatic Brain Injury 17. Epilepsy 18. ALS and Related Motor Neuron Disorders (Including Spastic Paraplegia) 19. Parkinsonian Syndromes 20. Huntington Disease 21. Alzheimer Disease and Other Dementias 22. Cerebrovascular Disease 23. Prion Disease Section IV: Infectious and Immune-mediated Diseases Affecting the Nervous System 24. Introduction 25. Inflammation in Neurological Disease 26. Inflammation in Psychiatric Disease 27. Infectious Diseases of the Nervous System 28. AIDS 29. Autoimmune Neurological Disorders: Idiopathic and Paraneoplastic 30. Multiple Sclerosis Section V: Diseases of Higher Function 31. Introduction 32. Disorders of Higher Cortical Function 33. Disorders of Frontal Lobe Function 34. Stress 35. Addictions 36. Sleep Disorders, Narcolepsy, and Restless Leg Syndrome 37. Anxiety Disorders and Post-traumatic Stress Disorder 38. Obsessive Compulsive Disorder 39. The Neurobiology of Schizophrenia 40. Bipolar Disorders 41. Pain 42. Headache and Migraine 43. Depression and Suicide Section VI: Diseases of the Nervous System and Society 44. Introduction 45. Ethical Issues that Emerge from Research (Basic) 46. Burden of Neurological Disease 47. Stress, Race, and Health Disparities
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Review Text

"This terrific book provides very broad coverage of the neurobiological basis of common neurological and psychiatric disorders...highly recommended to anyone who wants to keep up to date with the basic sciences involved in neuropsychiatric disorders. Score: 88 - 3 Stars" -- Doody's
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Review quote

"This terrific book provides very broad coverage of the neurobiological basis of common neurological and psychiatric disorders...highly recommended to anyone who wants to keep up to date with the basic sciences involved in neuropsychiatric disorders. Score: 88 - 3 Stars" --Doody's
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About Lewis P. Rowland

Affiliation: Professor of Neurology, Department of Neurology, University of Pittsburgh, Pennsylvania, U.S.A Over the past year, Dr. Zigmond and his research team have continued their studies of cellular and animal models to examine Parkinson's disease (PD), which they believe is a multi-factorial disorder. A major focus of the lab is the role of intracellular signaling cascades in determining the viability of dopamine (DA) neurons. They hypothesize, for example, that trophic factors such as GDNF and oxidative stress can both stimulate intracellular survival cascades, including those involving MAP kinases. They further believe that endogenous trophic factor expression can be enhanced by exercise which in turn can be neuroprotective. And they have evidence that protection also can derive from acute exposure to low levels of a neurotoxin, a form of preconditioning. Last year their work included studies of the impact of oxidative stress induced by 6-hydroxydopamine (6-OHDA), a DA analogue that is concentrated in DA cells and rapidly breaks down to form reactive oxygen species. Results from these and other studies suggest that DA neurons react to stress by initiating a set of protective responses. Learning more about these responses may provide insights into new treatment modalities for PD. In the coming year, Dr. Zigmond will continue to focus on understanding the strategies DA neurons use to reduce their vulnerability to intracellular stress. For example, studies are underway to determine if inhibition of trophic actor action or of kinase activation will block neuroprotection seen with exercise or GDNF or increase 6-OHDA toxicity. Some of these studies involve the preparation of molecular biological tools that maintain kinases in a constitutively or dominant negative state and/or localize a kinase to the cytoplasm or the nucleus. In addition, histochemical methods are being developed to quantify kinase levels in different cellular compartments of identified cells.
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