Naturally Occurring Benzodiazepines : Structure, Distribution and Function
Benzodiazepines (BZDs) including the widely used and mis-used drug Valium, have been in wide circulation in clinical practice since 1960 as sedatives, hypnotics, antidepressants and anticonvulsants. This work reveals the most recent research results following the discovery of naturally-occurring benzodiazepines in plants, animals and in particular the mammalian brain. The authors commence with a review of the search for endogenous BZD receptor ligands, and look at the occurrence of BZD in mammalian tissues and fluids. They investigate the dual origins of brain BZDs and BZD-like compounds, and the production of such compounds by microorganisms. Further chapters review regional BZD-like molecular changes after behavioural training; the identification and purification of new and naturally occurring physiologically active BZD-receptor ligands and the endogenous release monitored by microdialysis.
- Hardback | 156 pages
- 171.45 x 234.95 x 12.7mm | 386g
- 01 Jan 1994
- Taylor & Francis Ltd
- London, United Kingdom
Table of contents
Benzodiazepines and benzodiazepine-like molecules present in the brain; occurrence of benzodiazepine, benzodiazepine-like molecules and other ligands for the benzodiazepine receptor in nature; origin of brain benzodiazepine and benzodiazepine-like molecules; neurotransmitter systems involved in memory consolidation - the role of Gaba-A type receptors; endogenous benzodiazepine-like molecules and memory regulation; anxiety and brain benzodiazepine-like molecules; the role of benzodiazepine receptor ligands in the pathogenesis of hepatic encephalopathy; enzodiazepines - non-benzodiazepine endogenous allosteric modulators of Gaba(A) receptors; naturally occurring benzodiazepines - where we stand and where we go from here.