Myelin Biology and Disorders, Two-Volume Set

Myelin Biology and Disorders, Two-Volume Set


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With the completion of the "Human Genome Project" and the cloning and complete molecular description of the known myelin genes, the stage has been set for a detailed understanding of the biology of myelin, the disease processes affecting myelin and the potential for myelin repair and regeneration. Myelin Biology and Disorders brings together in one place, the recent advances in molecular and cellular biology along with visual data from MRI, confocal microscopy and high voltage EM techniques to provide new insights into disease mechanisms. This book represents a unique research reference on myelin biology and will serve as the definitive resource for both the professional clinical and basic scientist.
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Product details

  • Hardback | 1600 pages
  • 226 x 290 x 62mm | 4,059.94g
  • Academic Press Inc
  • San Diego, United States
  • English
  • Approx. 300 illustrations (150 in full color); Illustrations, unspecified
  • 0124395104
  • 9780124395107

Table of contents

Section I: Diseases of Myelin
Leukodystrophies: Overview and Classification
Multiple Sclerosis: Classification and Overview
Genetic Susceptibility and Epidemiology
Cellular Damage and Repair in MS
MRI Visualization of MS
Multiple Sclerosis (General Clinical and Trials)
Krabbe's Disease
Alexander's Disease
Pelizeaus-Merzbacher Disease
Guillain Barre Syndrome
Charcot-Marie-Tooth Disease
Infectious Demyelinating Diseases
Ischemic White Matter Damage
Protein Misfolding as a Disease Determinant

Section II: Animals Models of Human Disease
Experimental Allergic Encephalomyelitis
Experimental Models of Virus Induced Demyelination
Model's of Krabbe's Disease
Model's of Alexander's Disease
Model's of Pelizeaus Merzbacher Disease
Models of Charcot-Marie-Tooth Disease

Section III: The Myelin Genes and Products
Myelin Basic Protein Gene
Proteolipid Protein Gene
Myelin Associated Glycoprotein Gene
Myelin Oligodendrocyte Glycoprotein Gene
Cyclic Nucleotide Phosophohydrolase Gene
P0 Protein Gene
PMP 22 Gene
The Claudin 11 Gene
The Neurexin Gene
The Connexin 32 Gene
The Integrin Genes
The Periaxin Gene
The QK1 Gene

Section IV: Glial Cell Development
Invertebrate Glia
Neural Cell Specification During Development
Progenitor Cells of the Adult Human White Matter
Oligodendrocyte Lineage
Astrocyte Lineage
Schwann Cell Development
Olfactory Ensheathing Cells

Section V: Glial Cell and Myelin Functional Biology
Structure of the Myelinated Axon
Cell Biology of Myelin Assembly
The Transport and Assembly of Myelin Lipids
Functional Organization of the Nodes of Ranvier
Electrophysiologic Consequences of Myelination
Remyelination Through Engraftment
Remyelination by Endogenous Glia
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Review quote

"...Myelin Biology and Disorders represents a bravura achievement for all concerned and, now, a standard for the field."

"...a splendid book, an important addition to any serious clinical neuroscience bookshelf, and of lasting value..."
--BRAIN (2005)

"Lazzarini and his five section editors are to be applauded for overseeing the production of such a well-illustrated and thorough work.."
--Lloyd Davidson, Life Sciences Librarian, Northwestern University Seeley G. Mudd Library for Science and Engineering, E-Streams Vol 7 No 11, November 2004

"Under the baton of Robert Lazzarini, five distinguished editors have assembled a comprehensive treatise covering the origin and neurobiology of myelin-forming cells, the assembly of the myelin sheath and its often unforgiving diseases."
--Monique Dubois-Dalcq, MD, Department of Neuroscience, The Pasteur Institute, Paris, France

"This book comprises comprehensive, thoughtfully edited, uniformly first-rate chapters on myelination. It is the definitive work in the field."
--David R. Colman, Ph.D., Director, The Montreal Neurological Institute

"The two volumes on Glial Cell and Myelin Functional Biology serve as an impressive platform to showcase the rich literature on oligodendrocytes and Schwann cells in development and disease...The current and comprehensive style will make this book a standard for the field."
--Moses V. Chao, Molecular Neurobiology Program,
Skirball Institute of Biomolecular Medicine,
New York University School of Medicine, New York City, U.S.A.
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About Robert Lazzarini

Edited by Robert Lazzarini
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