Movement Disorders

Movement Disorders : Genetics and Models

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The use of animal models is a key aspect of scientific research in numerous fields of medicine. Movement Disorders, Second Edition vigorously examines the important contributions and application of animal models to the understanding of human movement disorders, and serves as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders.

The book is divided into sections on Parkinson's disease, Huntington's disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration, and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders.
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Product details

  • Hardback | 1258 pages
  • 223.52 x 279.4 x 48.26mm | 2,585.46g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 2nd edition
  • Approx. 200 illustrations (50 in full color); Illustrations, unspecified
  • 0124051952
  • 9780124051959
  • 2,134,184

Table of contents

Section I. Scientific Foundations

Section II. Parkinson Disease

Section III. Dystonia; Dystonia: Phenotypes and Genetics

Section IV. Huntington Disease

Section V. Tremor

Section VI. Myoclonus

Section VII. Tics

Section VIII. Paroxysmal Movement Disorders

Section IX. Tauopathies

Section X. Other Parkinsonian Syndromes: NBIA, MSA, PD+spasticity, PD+dystonia

Section XI. Ataxias

Section XII. Hereditary Spastic Paraplegia

Section XIII. Restless Legs Syndrome
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Review quote

" excellent resource for neurologists and researchers specializing in movement disorders." (Zbigniew K. Wszolek, Department of Neurology, Mayo Clinic Jacksonville in PARKINSONISM AND RELATED DISORDERS (2005)

"...this new textbook provides a comprehensive treatment of animal models used to study human movement disorders and should serve the neurologist, researcher, and other interested scientists very well."
--Dr. A.S. Fix, Central Product Safety, The Proctor and Gamble Co, Miami Valley Innovation Center, Cincinnati, OH, in VETERINARY PATHOLOGY (43:5) 2006
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About Mark LeDoux

Mark S. LeDoux, MD, PhD is a physician-scientist at the University of Tennessee Health Science Center. At present he holds a joint appointment as Professor in the Departments of Neurology, and Anatomy and Neurobiology. He specializes in the neurological subspecialty of movement disorders and treats patients at the University of Tennessee Medical Group and Memphis VA hospital. As an active clinical researcher, Dr. LeDoux's work has focused on the genetics and treatment of dystonia, Parkinson disease and Huntington disease. He has described Huntington disease in a nonagenarian and reported one of the world's largest pedigrees with HDL2. In the laboratory, Dr. LeDoux has published extensively on the genetics and molecular biology of dystonia, mechanisms of cell death in Parkinson's disease, animal models of dystonia and autism, and the neuroanatomy of motor systems. His work with the dt rat engendered paradigm shifts in dystonia and motor systems research. Dr. LeDoux's lab showed that familial and sporadic adult-onset primary dystonia may be associated with rare sequence variants in THAP1 and CIZ1.
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