The Mouse in Biomedical Research: Volume 1

The Mouse in Biomedical Research: Volume 1 : History, Wild Mice, and Genetics

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History, Wild Mice, and Genetics, the first volume in the four volume set, The Mouse in Biomedical Research, provides information about the history, biology and genomics of the laboratory mouse (Mus musculus), as well as basic information on maintenance and use of mouse stocks. Mouse origins and relationships are covered in chapters on history, evolutionary taxonomy and wild mice. Genetics and genomics of the mouse are covered in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome. Maintenance of laboratory mice is described in chapters on breeding systems for various types of strains and stocks and genetic monitoring. Use of the mouse as a model system for basic biomedical research is described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation. The information in Volume 1 serves as a primer for scientists new to the field of mouse research.
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Product details

  • Hardback | 352 pages
  • 221 x 279.4 x 22.9mm | 1,179.35g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 2nd edition
  • Approx. 100 illustrations; Illustrations, unspecified
  • 0123694558
  • 9780123694553
  • 1,535,887

Table of contents

1. Building a Better Mouse: One Hundred Years of Genetics and Biology

2. Systematics of the genus Mus

3. The Secret World of Wild Mice

4. Breeding Systems: Considerations, Genetic Fundamentals, Genetic Background, and Strain Types

5. Mouse Strain and Genetic Nomenclature: an Abbreviated Guide

6. The Mouse Genome

7. Gene Mapping

8. Genetic Monitoring

9. Cytogenetics

10. Mouse Embryology: Research Techniques and a Comparison of Embryonic Development between Mouse and Man

11. Gamete and Embryo Manipulation

12. Chemical Mutagenesis in Mice

13. Gene-Specific Mutagenesis

14. Gene Transfer Studies Using Mouse Models

15. Mouse and Human Pluripotent Stem Cells

16. Drugs and the Mouse: Pharmacology, Pharmacogenetics, and Pharmacogenomics
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