Molecular Toxicology

Molecular Toxicology

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Description

This book presents the biochemical and molecular biological fundamentals underlying toxicology and drug metabolism. It covers xenobiotic biotransformation; reactive intermediates and their interactions with macromolecules; cloning, expression, and analysis of the enzymes of biotransformation; and molecular toxicology of aromatic amines, nitrosames, polycyclic aromatic hydrocarbons, and chlorinated compounds.show more

Product details

  • Hardback | 384 pages
  • 185.4 x 260.4 x 27.7mm | 1,114.72g
  • Oxford University Press Inc
  • New York, United States
  • English
  • numerous line figures, tables
  • 0195093402
  • 9780195093407

Table of contents

Introduction; 1. Biochemical Background; 2. Molecular biology and its applications in toxicology; 3. Biological oxidations; 4. Superoxide and superoxide dismutase; 5. Hydrogen peroxide and catalase; 6. The respiratory burst; 7. Lipid Peroxidation; 8. Oxidative stress in the erythrocyte; 9. Introduction to xenobiotic metabolism; 10. Clucuronide formation; 11. Glutathione and detoxication; 12. Arylamine N-Acetyltransferase; 13. Sulfotransferase; 14. Cytochrom P-450; 15. The AH receptor and the toxicity of chlorinated aromatic compounds; 16. Identification of DNA adducts; 17. Chemical mutagenesis; 18. Carcinogenesis: the genetic targets; 19. Polycyclic aromatic hydrocarbon carcinogenesis; 20. Aromatic amines and other N-aryl compoundsshow more

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