Molecular Paradigms of Infectious Disease

Molecular Paradigms of Infectious Disease : A Bacterial Perspective

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This volume provides an overview of host genetic factors that provide complete or partial resistance to infection, that influence the clinical outcome of infection, or that confer the capacity to remain healthy during infection. This book covers the most recent advances in the field and explores how progress in knowing the genetic basis of infectious diseases could lead to new insights in understanding and combating them.
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Product details

  • Hardback | 646 pages
  • 155 x 235 x 33.27mm | 1,267g
  • New York, NY, United States
  • English
  • 2006 ed.
  • 17 Tables, black and white; 6 Illustrations, color; 132 Illustrations, black and white; XII, 646 p. 138 illus., 6 illus. in color.
  • 0387309179
  • 9780387309170

Back cover copy

This comprehensive volume, written by leading authors in the field, provides a fundamental understanding of the complex cellular and molecular processes that are important for bacterial virulence and the infectious disease process. Written in a clear and engaging manner, the book highlights key techniques and methodologies that have driven recent discoveries in bacterial pathogenesis, major structures and mechanisms in bacteria that are important for the pathogenesis of these organisms, the regulation of these virulence determinants by global regulators, and bacterial biowarfare agents. Molecular Paradigms of Infectious Disease: A Bacterial Perspective is an ideal book for students, microbiologists, immunologists and scientists and researchers of bacterial pathogenesis.
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Table of contents

Genetic Analysis of Bacterial Pathogenesis.- Genetic Exchange in Bacteria and the Modular Structure of Mobile DNA Elements.- Genomics and the Use of Genomic Tools to Study Pathogenic Bacteria.- Pathogenicity Islands and Bacterial Virulence.- Capsules.- Bacterial Cell Walls.- Mechanisms of Bacterial Adhesion and Consequences of Attachment.- Bacterial Invasion into Non-Phagocytic Cells.- Bacterial Protein Secretion Mechanisms.- Toxins as Host Cell Modulators.- Quorum Sensing: Coordinating Group Behavior Through Intercellular Signals.- The Role of Sigma Factors in Regulating Bacterial Stress Responses and Pathogenesis.- Two-Component Regulatory Systems.- Oxidative Stress Systems in Bacteria: Four Model Organisms.- Bacterial Biowarfare Agents.
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