Molecular Nutrition and Diabetes

Molecular Nutrition and Diabetes : A Volume in the Molecular Nutrition Series

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Molecular Nutrition and Diabetes: A Volume in the Molecular Nutrition Series focuses on diabetes as a nutritional problem and its important metabolic consequences. Fuel metabolism and dietary supply all influence the outcome of diabetes, but understanding the pathogenesis of the diabetic process is a prelude to better nutritional control.

Part One of the book provides general coverage of nutrition and diabetes in terms of dietary patterns, insulin resistance, and the glucose-insulin axis, while Part Two presents the molecular biology of diabetes and focuses on areas such as oxidative stress, mitochondrial function, insulin resistance, high-fat diets, nutriceuticals, and lipid accumulation. Final sections explore the genetic machinery behind diabetes and diabetic metabolism, including signaling pathways, gene expression, genome-wide association studies, and specific gene expression. While the main focus of each chapter is the basic and clinical research on diabetes as a nutritional problem, all chapters also end with a translational section on the implications for the nutritional control of diabetes.
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Product details

  • Hardback | 400 pages
  • 216 x 276 x 25.4mm | 1,340g
  • Academic Press Inc
  • San Diego, United States
  • English
  • colour illustrations
  • 0128015853
  • 9780128015858
  • 951,920

Table of contents

Section 1: General and Introductory Aspects

1. Nutrition and diabetes: general aspects

Ana M. Wagner, Julia Charlotte Wiebe, Rosa M. Sanchez-Hernandez and Lidia Garcia-Perez

2. Dietary patterns and insulin resistance

Marcio A. Torsoni, Adriana Souza Torsoni and Marciane Milanski

3. Beta cell metabolism, insulin production and secretion; metabolic failure resulting in diabetes

Younan Chen, Vinicius Fernandes Cruzat and Philip Newsholme

4. Diet-gene interactions in the development of diabetes

Jose M. Ordovas

5. Pathogenesis of type 1 diabetes: role of dietary factors

Julie Christine Antvorskov, Karsten Buschard and Knud Josefsen

Section 2: Molecular biology of the cell

6. Oxidative stress in diabetes mellitus: molecular aspects: implications for the diet

Lu Cai

7. Muscle protein in type 2 diabetes: Molecular aspects

Antonio Zorzano

8. Mechanisms whereby wholegrain cereals modulate the prevention of type-2 diabetes

Knud Erik Bach Knudsen, Kjeld Hermansen, Mette Skou Hedemann and Merete Lindberg Hartvigsen

9. Peroxisome proliferator activated receptors -PPARs - in glucose control

Massimo Collino and Fausto Chiazza

10. High-fat diets and beta-cell dysfunction: molecular aspects

Carla B. Collares-Buzato

11. Native fruits, anthocyanins in nutraceuticals and the insulin receptor/insulin receptor substrate-1/Akt/ forkhead box protein pathway

N.R.V. Dragano and Anne y Castro Marques

12. Influence of dietary factors on gut microbiota: role on insulin resistance and diabetes mellitus

Gemma Xifra Villarroya, Eduardo Esteve and J.M Fernandez-Real

13. Molecular aspects of Glucose regulation of pancreatic beta-cells

Rosa Gasa, Ramon Gomis, Anna Novials and Joan-Marc Servitja

14. Metals and signalling in diabetes

Lu Cai

15. Cocoa flavonoids and insulin signalling

Sonia Ramos, M.A. Martin and Luis Goya

16. Dietary proanthocyanidin modulation of pancreatic beta-cells: molecular aspects

Montserrat Pinent, Mayte Blay, Anna Ardevol and Noemi Gonzalez-Abuin

17. Dietary whey protein and Type 2 diabetes: molecular aspects

Jaime Amaya-Farfan, Priscila Neder Morato, Carolina Soares Moura and Pablo Lollo

18. Dietary fatty acids and C-reactive proteins in diabetes

Giovanni Annuzzi, Ettore Griffo, Giuseppina Costabile and Lutgarda Bozzetto

19. Alcoholic beverage and diabetes: cellular and molecular effects

Suzanne de la Monte

Section 3: Genetic machinery and its function

20. Alleles and risk of diabetes

Valeriya Lyssenko

21. Micro RNAs in diabetes

Louise Torp Dalgaard, Sofia Anna Saloe, Anja Elaine Sorensen and Julian Geiger

22. Diabetes mellitus and intestinal Niemann-Pick C1-Like1 gene expression

W. A. Alrefai, Pooja Malhotra, Ravinder K. Gill and Pradeep K. Dudeja

23. Dietary long-chain omega-3 polyunsaturated fatty acids and inflammatory gene expression in type 2 diabetes

Manohar Lal Garg

24. Polymorphisms, carbohydrates, fat and type 2 diabetes: the example of insulin receptor substrate 1 (IRS1)

Jose Lopez-Miranda

25. Genetic basis linking variants for diabetes and obesity with breast cancer

Vijay Kumar Kutala

26. Genetic determinants of pathways underlying 25(OH) vitamin D deficiency predisposing to type 1 and type 2 diabetes mellitus

Dharambir K. Sanghera and Piers R. Blackett

27. NRF2-mediated gene regulation and glucose homeostasis

Masayuki Yamamoto and Akira Uruno

28. Hepatic mitochondrial fatty acid oxidation and type 2 diabetes

Abdelhak Mansouri, Wolfgang Langhans, Jean Girard and Carina Prip-Buus

29. The wnt signaling pathway and glucose homeostasis

T. Jin
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About Didac Mauricio

Didac Mauricio, MD, PhD, is currently Chief Physician and acting Head of the Department of Endocrinology & Nutrition, University Hospital Germans Trias i Pujol, affiliated with the Autonomous University in Barcelona. After receiving his medical degree with honors from the University of Barcelona, Dr. Mauricio completed his fellowship in Endocrinology & Nutrition at Hospital de Sant Pau, Autonomous University of Barcelona, Spain. In 1993, he presented his PhD thesis at the School of Medicine, Autonomous University of Barcelona. From 1994 to 1995, he was a post-doctoral research fellow for Professor J. Nerup at the Steno Diabetes Center & Hagedorn Research Institute in Gentofte, Denmark. Dr. Mauricio has delivered numerous invited lectures at major medical conferences, and has been principal investigator of several research projects funded by national and international agencies. He keeps a strong interest in current clinical issues in diabetes management, including randomized clinical trials, and is currently involved in projects dealing with the study of immune, metabolic, and genetic markers of autoimmune diabetes, and diabetic micro- and macroangiopathic complications. Dr. Mauricio has published more than 130 peer-reviewed articles and has contributed to multiple books, and is currently the Editor-in Chief of Endocrinologia y Nutricion, the official journal of the Spanish Society of Endocrinology & Nutrition.
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