Molecular Diagnostics

Molecular Diagnostics

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The 2e of Molecular Diagnostics, the only book dealing with diagnosis on a molecular level, discusses current molecular biological techniques used to identify the underlying molecular defects in inherited disease. The book delves further into the principle and brief description of the technique, followed by examples from the authors' own expertise. Contributors to the 2e are well-known experts in their field, and derive from a variety of disciplines, to ensure breadth and depth of coverage. Molecular Diagnostics, 2e , is a needed resource for graduate students, researchers, physicians and practicing scientists in molecular genetics and professionals from similar backgrounds working in diagnostic laboratories in academia or industry, as well as academic institutions and hospital libraries.
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Product details

  • Hardback | 616 pages
  • 218.44 x 279.4 x 27.94mm | 1,814.36g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 2nd edition
  • 0123745373
  • 9780123745378
  • 1,530,425

Table of contents

1. Molecular Diagnostics: Past, Present, and Future; 2. Allele-Specific Mutation Detection; 3. Enzymatic and Chemical Cleavage Methods to Identify Genetic Variation; 4. Mutation Detection by Single Strand Conformation Polymorphism and Heteroduplex Analysis; 5. Capillary Electrophoresis; 6. Temperature and Denaturing Gradient Gel Electrophoresis; 7. Real-Time Polymerase Chain Reaction; 8. Pyrosequencing; 9. Application of Padlock and Selector Probes in Molecular Medicine; 10. Molecular Cytogenetics in Molecular Diagnostics; 11. Analysis of Human Splicing Defects Using Hybrid Minigenes; 12. Detection of Genomic Duplications and Deletions; 13. Multiplex Ligation-Dependent Probe Amplification (MLPA) and Methylation-Specific (MS)-MLPA: Multiplex Detection of DNA/mRNA Copy Number and Methylation Changes; 14. Molecular Techniques for DNA Methylation Studies; 15. High-Resolution Melting Curve Analysis for Molecular Diagnostics; 16. DNA Microarrays and Genetic Testing; 17. Arrayed Primer Extension Microarrays for Molecular Diagnostics; 18. Application of Proteomics to Disease Diagnostics; 19. RNA-Based Variant Detection: The Protein Truncation Test; 20. Protein Diagnostics by Proximity Ligation: Combining Multiple Recognition and DNA Amplification for Improved Protein Analyses; 21. Mass Spectrometry and its Applications to Functional Proteomics; 22. Pharmacogenetics and Pharmacogenomics: Impact on Druge Discovery and Clinical Care; 23. Nutrigenomics: Integrating Genomic Approaches into Nutrition Research; 24. Novel Next-Generation DNA Sequencing Techniques for Ultra High-Throughput Applications in Bio-Medicine; 25. Locus-Specific and National/Ethnic Mutation Databases: Emerging Tools for Molecular Diagnostics; 26. Molecular Diagnostic Applications in Forensic Science; 27. Mass Disaster Victim Identification ASsisted by DNA Typing; 28. Detection of Highly Pathogenic Viral Agents: Implications for Therapeutics, Vaccines and Biodefense; 29. Identification of Genetically Modified Organisms; 30. Molecular Diagnostics and Comparative Genomics in Clinical Microbiology; 31. Genetic Monitoring of Laboratory Rodents; 32. Safety Analysis in Retroviral Gene Therapy: Identifying Virus Integration Sites in Gene-Modified Cells; 33. Preimplantation Genetic Diagnosis; 34. Automated DNA Hybridization and Detection; 35. The Use of Microelectronic-Based Techniques in Molecular Diagnostic Assays; 36. Human Gene Patents and Genetic Testing; 37. Genetic Counseling and Ethics in Molecular Diagnostics; 38. Genetic Testing and Psychology; 39. General Considerations Concerning Safety in Biomedical Research Laboratories; 40. Quality Management in the Laboratory
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About Wilhelm Ansorge

Dr. George Patrinos is an Associate Professor at the University of Patras School of Health Sciences (Department of Pharmacy) in Patras, Greece with Adjunct positions in Rotterdam, the Netherlands and Al-Ain, United Arab Emirates. His research interests span the fields of molecular diagnostics, high-throughput mutation screening, the development of online mutation diagnostic tools, and the implementation of genomics in healthcare, particularly for health systems in developing countries. George Patrinos has published more than 170 scientific papers in peer reviewed journals on topics related to genetics, genomic medicine, pharmacogenomics, molecular diagnostics, and social and economic evaluation for genomic medicine. Dr. Patrinos is also the co-author of Economic Evaluation in Genomic Medicine (2015) and co-Editor of Molecular Diagnostics, Second Edition (2009), both published by Elsevier, and serves as Communicating Editor for the journal Human Mutation. Additionally, he is co-organizer of the international meeting series "Golden Helix Symposia" and "Golden Helix Pharmacogenomics Days". Dr. George Patrinos is a Senior Research Scientist in Erasmus University Medical Center in Rotterdam, the Netherlands. He has many years of research experience in the field of Molecular Diagnostics. One of his current research interests is high throughput mutation screening and development of National mutation databases as online diagnostic tools. Prof. Dr. Wilhelm Ansorge is a Senior Research Scientist and coordinator of the Biochemical Instrumentation Programme at the European Molecular Biology Laboratory in Heidelberg, Germany. His research interests include the development of the first complete Human Genome microarray, with numerous applications in gene expression studies and high-throughput Molecular Diagnostics.
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