Molecular and Cellular Immunobiology of the Maternal Foetal Interface

Molecular and Cellular Immunobiology of the Maternal Foetal Interface

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This is the third volume in a series focusing on reproductive immunology. The book examines the molecular and cellular nature of immune signalling between mother and foetus, the role that this signalling plays in normal maintenance of pregnancy and how its aberrations may affect fetal development. One of the most interesting concepts to evolve from this work is that the "molecular languages" of the haematopoietic/lymphoid and trophoblast decidua systems (and possibly the nervous system) are closely related, and in some cases, may be identical. In analyzing the central problem of reproductive immunology from many different scientific points of view, the authors make clear that our somewhat parochial view of different biological phenomena will have to be revised and broadened as we find more evidence of universitality in biological more

Product details

  • Hardback | 344 pages
  • 150 x 230 x 27mm | 813g
  • Oxford University Press Inc
  • New York, United States
  • English
  • 102 illustrations, index
  • 019506304X
  • 9780195063042

Table of contents

The molecular and cellular nature of maternal-fetal immune signalling: an overview; PART I: FETAL MAJOR HISTOCOMPATIBILITY COMPLEX: Class I gene products in the human placenta and extraplacenta membranes; Unusual HLA class I expression on human cytotrophoblast cells, and on a choriocarcinoma cell line; Genetic studies of the MHC region in human recurrent spontaneous abortion; Characterization of the class I antigen of the rat placenta encoded by cDNA clone pARI.5; Analysis of MHC-linked genes affecting development; Expression of major histocompatibility complex class I genes in murine extra-embryonic tissues; PART II: DECIDUAL EFFECTOR CELLS: Human trophoblast-decidua interaction in vitro; Immune cell populations in the human early pregnancy decidua; Immunobiological features of murine trophoblast; Inhibition of macrophage and T-lymphocyte functions in the placenta and decidua during listeriosis: implications for tolerance of the fetoplacental allograft; Is there an essential requirement for bone marrow-derived cells at the fetomaternal interface during successful pregnancy? A study of pregnancies in immunodeficient mice; PART III: CYTOKINES: In vitro models of maternal fetal interface; Adverse effects of immune cell products in pregnancy; T-cell products in implantation: role of putative suppressor factors; Interferons secreted by sheep conceptuses are involved in maternal recognition of pregnancy; Colony-stimulating factor-1: a growth factor for trophoblasts?; The placenta as an immune-endocrine interface: placental cells as targets for lymphohaematopoietic cytokine stimulation; Immunological and endocrinological factors that contribute to successful pregnancy; Role of a factor related to Transforming Growth Factor Beta-2 in successful pregnancy; more