Molecular and Cellular Basis of Metastasis: Road to Therapy: Volume 132

Molecular and Cellular Basis of Metastasis: Road to Therapy: Volume 132

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Description

Molecular and Cellular Basis of Metastasis: Road to Therapy, the latest in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, with this volume covering the molecular and cellular basis of metastasis.
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Product details

  • Hardback | 390 pages
  • 152 x 229 x 22.86mm | 770g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0128041404
  • 9780128041406

Review quote

Praise for the Serial: "This classic and essential series presents critical overviews on select aspects of both cancer research and the basic underlying sciences." --American Scientist "Excellent, highly informative, in-depth reviews...expertly written, up-to-date, and well-referenced." --Journal of Medicinal Chemistry "This is a series that has a long tradition of excellence in the field of cancer biology." --Doody's Publishing Reviews
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About Danny R Welch

University of Kansas Cancer Center, USA Paul B. Fisher, M.Ph., Ph.D., is an accomplished molecular biologist investigating the mechanisms involved in cancer development and progression in order to define improved methods for cancer prevention, detection and therapy. Fisher pioneered a powerful technique to study gene expression in specific tissues or cell types known as subtraction hybridization, which he has used to identify genes involved in many important and medically relevant physiological processes including cancer, neurodegeneration and infectious diseases. Studies in his laboratory focus on understanding the molecular and biochemical reasons for cancer development with a specific focus on understanding how cancers spread, a process called metastasis. The ultimate aim is to use this collected knowledge to bring new, more effective prevention techniques, diagnostic approaches and therapies from the laboratory bench to the patient's bedside. This is epitomized by his studies involving mda-7/IL-24, a gene that was discovered in his laboratory and has displayed significant clinical efficacy in a phase 1 clinical trial when injected directly into advanced cancers using a form of viral gene therapy. Using a novel cancer terminator virus, Ad.5/3-CTV, that is designed to replicate only within cancer cells while delivering the immune-modulating and toxic mda-7/IL-24 gene, Fisher and his clinical colleagues are developing a clinical trial in patients with glioblastoma multiforme, the most common and deadly form of brain cancer. Fisher has been consistently funded by the National Institutes of Health (NIH) over the past 35 years and is among the top 5 percent of NIH funded investigators during this period. He has published over 500 primary papers and reviews, served on numerous NIH study sections and government and private grant review panels and has over 55 issued patents. He is the recipient of multiple National Cancer Institute (NCI) Program Project Grants; investigator initiated R01 grants from the NIH, NCI and National Institute of General Medical Sciences (NIGMS); private foundation grants from the National Foundation for Cancer Research and the Samuel Waxman Cancer Research Foundation; and an Institutional Research and Academic Career Development Award from the NIH focusing on preparing students from groups underrepresented in the sciences for research careers. Fisher is Professor and Chair of the Department of Human and Molecular Genetics at the Virginia Commonwealth University (VCU) School of Medicine, Founding Director of the VCU Institute of Molecular Medicine and Thelma Newmeyer Corman Chair in Cancer Research and co-leader of the Cancer Molecular Genetics research program at VCU Massey Cancer Center.
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Table of contents

1. Imaging of metastases
Paul B. Fisher
2. Dormancy
Julio Aguirre-Ghiso
3. Host genetics regulating metastasis
Kent Hunter and Nigel Crawford
4. BRMS1
Douglas R. Hurst, Christa Manton and Danny R. Welch
5. Immune regulation of metastasis
Brian Ruffell
6. microRNA and metastasis
Li Ma
7. Different mechanisms of tumor migration
Peter Friedl
8. Cytokine regulation of metastasis/tumorigenicity
Nikki Cheng
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