Molecular and Cell Biology of Cancer

Molecular and Cell Biology of Cancer : When Cells Break the Rules and Hijack Their Own Planet

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Description

This textbook takes you on a journey to the basic concepts of cancer biology. It combines developmental, evolutionary and cell biology perspectives, to then wrap-up with an integrated clinical approach.

The book starts with an introductory chapter, looking at cancer in a nut shell. The subsequent chapters are detailed and the idea of cancer as a mass of somatic cells undergoing a micro-evolutionary Darwinian process is explored. Further, the main Hanahan and Weinberg "Hallmarks of Cancer" are revisited. In most chapters, the fundamental experiments that led to key concepts, connecting basic biology and biomedicine are highlighted. In the book's closing section all of these concepts are integrated in clinical studies, where molecular diagnosis as well as the various classical and modern therapeutic strategies are addressed.

The book is written in an easy-to-read language, like a one-on-one conversation between the writer and the reader, without compromising the scientific accuracy. Therefore, this book is suited not only for advanced undergraduates and master students but also for patients or curious lay people looking for a further understanding of this shattering disease
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Product details

  • Paperback | 216 pages
  • 168 x 240 x 17mm | 480g
  • Cham, Switzerland
  • English
  • 1st ed. 2019
  • 77 Tables, color; 71 Illustrations, color; IX, 216 p. 71 illus. in color.
  • 3030118118
  • 9783030118112

Back cover copy

This textbook takes you on a journey to the basic concepts of cancer biology. It combines developmental, evolutionary and cell biology perspectives, to then wrap-up with an integrated clinical approach.

The book starts with an introductory chapter, looking at cancer in a nut shell. The subsequent chapters are detailed and the idea of cancer as a mass of somatic cells undergoing a micro-evolutionary Darwinian process is explored. Further, the main Hanahan and Weinberg "Hallmarks of Cancer" are revisited. In most chapters, the fundamental experiments that led to key concepts, connecting basic biology and biomedicine are highlighted. In the book's closing section all of these concepts are integrated in clinical studies, where molecular diagnosis as well as the various classical and modern therapeutic strategies are addressed.

The book is written in an easy-to-read language, like a one-on-one conversation between the writer and the reader, without compromising the scientific accuracy. Therefore, this book is suited not only for advanced undergraduates and master students but also for patients or curious lay people looking for a further understanding of this shattering disease
show more

Table of contents

PREFACE



CHAPTER 1



Molecular and Cell Biology of Cancer when cells break the rules and hijack their own planet



CHAPTER 2



Cancer as an Evolutionary Process



CHAPTER 3



Cell signaling in cancer



Chapter 4



"The cell cycle, cytoskeleton and cancer"



CHAPTER 5



Genomic Instability: DNA Repair and Cancer



CHAPTER 6



Cell metabolism in cancer - an energetic switch



CHAPTER 7



Cancer immunoediting and hijacking of the immune system



CHAPTER 8



Angiogenesis - vessels recruitment by tumor cells



CHAPTER 9



Tumor niche disruption and metastasis: the role of epithelial-mesenchymal transition (EMT)



CHAPTER 10



Case studies - Molecular Pathology perspective and impact on oncologic patients' management



INDEX
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Review quote

Professor Doctor Rita Fior has received the following awards:


Mar 2011 Award: BioMED Central Research Award, Best paper 2011 Neuroscience category for Fior, Vilas-Boas et al, 2011
Mar 2004 Award: YOUNG GENETICIST OF THE YEAR 2004, awarded by the British Genetics Society and Promega

Outside the United States, the Champalimaud Centre for the Unknown ranked ahead of the prestigious Vienna's Institute of Molecular Biotechnology (Austria) and the Center for Molecular Medicine (Austria) as best International Research Institute.
Jo o Barata was awarded the Silver Medal for Distinct Services from the Portuguese Ministry of Health.
M nica Bettencourt Dias has been the Pfizer award for Basic Research, the Keith Porter Prize and was inducted as a member of EMBO in 2015. Professor Dc. Ant nio Parreira is the Director of the Clinical Center of the Champalimaud Foundation.
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About Rita Fior

Professor Dr. Rita Fior teaches Molecular and Cell Biology of Cancer at the Faculty of Sciences in the University of Lisbon, Portugal. She is also a Principal Investigator at the Champalimaud Foundation, a renowned state-of-the-art center for Science. She has worked with Julian Lewis (Emeritus Scientist and Fellow of the Royal Society, CRUK).
Professor Dr. Rita Zilhao has been teaching for more than 20 years at the Faculty of Sciences in the University of Lisbon, Portugal. At this moment she is responsible for 3 courses: Genetic and Molecular Biology, Basics of Molecular Biology and Molecular and Cell Biology of Cancer. She is the coordinator of the Molecular and Genetic Biology Bachelor Program.
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