Molecular Biological Markers for Toxicology and Risk Assessment
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Molecular Biological Markers for Toxicology and Risk Assessment

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Description

Molecular Biological Markers for Toxicology and Risk Assessment provides an introduction to the exciting field of biomarkers and their use in toxicology and risk assessment. In recent years, new classes of molecular biomarkers capable of detecting early manifestations of ongoing chemical-induced cell injury and cell death have been developed as a result of advances in analytical chemistry, molecular biology, and computational modeling. The interplay between these emergent tools of science has resulted in new insights into initial mechanisms of chemical-induced toxicity and carcinogenicity.

Molecular Biological Markers for Toxicology and Risk Assessment guides the reader through a broad range of molecular biological markers, including the "omic" biomarkers, and provides an examination of the various elements in the evolution of these modern tools. It then explores possible ways in which these markers may be applied to advance the field of chemical risk assessment. Since molecular biomarkers and related technologies are inherently complex, the book concludes with a section on risk communication in order that readers may appreciate both the strengths and limitations of molecular biological marker approaches to risk assessment practice.
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Product details

  • Hardback | 164 pages
  • 191 x 235 x 15.24mm | 540g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 012809589X
  • 9780128095898

Table of contents

Preface
1. Introduction
2. Historical Development of Biomarkers
3. Computational Toxicology
4. Omic Biological Markers
5. Validation of Biological Markers for Epidemiological Studies
6. Technical Translational Analysis of Biological Marker Data
7. QA/QC of Biological Marker Data Sets
8. Translation of Biomarkers for Human Clinical and Epidemiological Studies
9. Risk Communication of Molecular Biological Marker Information
10. Future Research Directions
Appendices
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About Bruce A. Fowler

Dr. Fowler began his scientific career at the National Institute of Environmental Health Sciences prior to becoming Director of the University of Maryland System-wide Program in Toxicology and Professor at the University of Maryland School of Medicine. He then served as Associate Director for Science in the Division of Toxicology and Environmental Medicine at Agency for Toxic Substances and Disease Registry (ATSDR). He is currently a private consultant and Co-owner of Toxicology Risk Assessment Consulting Services (TRACS), LLC. In addition, Dr. Fowler serves as an Adjunct Professor, Emory University Rollins School of Public Health and Presidents Professor of Biomedical Sciences, Center for Alaska Native Health Research (CANHR) at the University of Alaska- Fairbanks. Dr. Fowler, is an internationally recognized expert on the toxicology of metals and has served on a number of State, National and International Committees in his areas of expertise. These include the Maryland Governor's Council on Toxic Substances (Chair), various National Academy of Sciences / National Research Council Committees, the USEPA Science Advisory Board and Fulbright Scholarship review committee for Scandinavia (Chair, 2000-2001). ). In 2016, he became an Inaugural Member of the Fulbright 1946 Society. He has also served as a temporary advisor to the World Health Organization (WHO) and the International Agency for Research Against Cancer (IARC) for a number of toxicology and risk assessment issues and has been recently appointed as a member of the Joint FAO/WHO Expert Committee on Food Additives (JECFA) for the period 2016-2020. Dr. Fowler has been honored as a Fellow of the Japanese Society for the Promotion of Science (JSPS), a Fulbright Scholar and Swedish Medical Research Council Visiting Professor at the Karolinska Institute, Stockholm, Sweden and elected as a Fellow of the Academy of Toxicological Sciences. His more recent awards include a CDC/ATSDR, Honor Award for Excellence in Leadership Award 2010, The USP Toxicology Committee 2010-2015. The USP Elemental Impurities Panel and the 2014 U.S. Pharmacopea Award for an Innovative Response to Public Health Challenges (Group Award). He was appointed to the USP Nanotechnology Subcommittee in 2015- .Dr. Fowler was previously elected to the Council of the Society of Toxicology (2005-2007), the Board of Directors of the Academy of Toxicological Sciences (2006-2009), and more recently, to the Council of the Society for Risk Analysis (2014-2017He is the Federal Legislative and National Active and Retired Federal Employees Association (NARFE)-PAC Chair for the Rockville Maryland Chapter of NARFE. Dr. Fowler is the current President of the Rotary Club of North Bethesda, Maryland (2016-2017) and was selected as Rotarian of the Year in 2015 for his work in developing a taxi-based program to help persons with disabilities gain independence via reliable transportation to work. Dr. Fowler is the author of over 260 research papers and book chapters dealing with molecular mechanisms of metal toxicity, molecular biomarkers for early detection of metal-induced cell injury and application of computational toxicology for risk assessment. He has been the editor, co-editor or author of 8 books or monographs on metal toxicology and mechanisms of chemical - induced cell injury, molecular biomarkers and risk assessment and computational toxicology. Dr. Fowler is currently focused on the global problem of electronic waste in developing countries. He serves on the editorial boards of a number of scientific journals in toxicology and is an Associate Editor of the journal Toxicology and Applied Pharmacology and a past Associate Editor of Environmental Health Perspectives (2007-2016).
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