Modifications of Nuclear DNA and its Regulatory Proteins: Volume 101
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Modifications of Nuclear DNA and its Regulatory Proteins: Volume 101

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Description

DNA methylation is essential for the normal development and functioning of organisms. This volume discusses the latest developments in this very active field of research. It presents the evolution of DNA methylation, mammalian DNA methyltransferases, DNA methylation and demethlyation, DNA methylation and silencing and the role it plays in medicine including cancer.
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Product details

  • Hardback | 502 pages
  • 154.94 x 231.14 x 33.02mm | 793.78g
  • Academic Press Inc
  • San Diego, United States
  • English
  • New
  • 0123876850
  • 9780123876850

Table of contents

Introduction - Epiphanies in Epigenetics Xiaodong Cheng and Robert M. Blumenthal
Section I. EVOLUTION OF DNA METHYLATION

The natural history of eukaryotic DNA methylation systems Lakshminarayan M. Iyer, Saraswathi Abhiman, L. Aravind
Evolution of histone methyltransferases and demethylases L. Aravind
DNA methylation in Drosophila - A critical evaluation Veiko Krauss and Gunter Reuter
DNA Methylation in Zebrafish Mary G Goll and Marnie E Halpern
Seciton II. MAMMALIAN DNA METHYLTRANSFERASES - STRUCTURE AND FUNCTION

Dnmt1 - structure and function Zeljko M. Svedruzic
The DNMT3 family of MAMMALIAN de novo DNA methyltransferases Frederic Chedin
Seciton III. DNA METHYLATION AND DEMETHYLATION

Recruitment of Dnmt1: Roles of the SRA protein Np95 (Uhrf1) and other factors Jafar Sharif & Haruhiko Koseki
Regulation of Expression and Activity of DNA (cytosine-5) methyltransferases in mammalian cells Shannon R. Morey Kinney and Sriharsa Pradhan
Mechanistic and functional links between histone methylation and DNA methylation Taiping Chen
Section IV. DNA METHYLATION IN MEDICINE

RNA mediated silencing mechanisms in mammalian cells Anton Wutz
Biological functions of methyl-CpG binding proteins Pierre-Antoine Defossez and Irina Stancheva
Section V. DNA METHYLATION IN MEDICINE

Diseases associated with imprinting J.F. Wilkins and F. Ubeda
DNA methylation changes in cancer Minoru Toyota and Eiichiro Yamamoto
Epigenetic biomarkers J. Tost
Distribution of methylation at the single-nucleotide level E. Wong
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Review quote

PRAISE FOR THE SERIES "Full of interest not only for the molecular biologist--for whom the numerous references will be invaluable--but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."--British Medical Journal
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