Missing Data in Longitudinal Studies

Missing Data in Longitudinal Studies : Strategies for Bayesian Modeling and Sensitivity Analysis

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Drawing from the authors' own work and from the most recent developments in the field, Missing Data in Longitudinal Studies: Strategies for Bayesian Modeling and Sensitivity Analysis describes a comprehensive Bayesian approach for drawing inference from incomplete data in longitudinal studies. To illustrate these methods, the authors employ several data sets throughout that cover a range of study designs, variable types, and missing data issues. The book first reviews modern approaches to formulate and interpret regression models for longitudinal data. It then discusses key ideas in Bayesian inference, including specifying prior distributions, computing posterior distribution, and assessing model fit. The book carefully describes the assumptions needed to make inferences about a full-data distribution from incompletely observed data. For settings with ignorable dropout, it emphasizes the importance of covariance models for inference about the mean while for nonignorable dropout, the book studies a variety of models in detail. It concludes with three case studies that highlight important features of the Bayesian approach for handling nonignorable missingness.

With suggestions for further reading at the end of most chapters as well as many applications to the health sciences, this resource offers a unified Bayesian approach to handle missing data in longitudinal studies.
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Product details

  • Hardback | 328 pages
  • 154.94 x 236.22 x 22.86mm | 589.67g
  • Chapman & Hall/CRC
  • Boca Raton, FL, United States
  • English
  • 1000 equations; 43 Tables, black and white; 21 Illustrations, black and white
  • 1584886099
  • 9781584886099
  • 1,135,769

Table of contents

PREFACE
Description of Motivating Examples
Overview
Dose-Finding Trial of an Experimental Treatment for Schizophrenia
Clinical Trial of Recombinant Human Growth Hormone (rhGH) for Increasing Muscle Strength in the Elderly
Clinical Trials of Exercise as an Aid to Smoking Cessation in Women: The Commit to Quit Studies
Natural History of HIV Infection in Women: HIV Epidemiology Research Study (HERS) Cohort
Clinical Trial of Smoking Cessation among Substance Abusers: OASIS Study
Equivalence Trial of Competing Doses of AZT in HIV-Infected Children: Protocol 128 of the AIDS Clinical Trials Group
Regression Models
Overview
Preliminaries
Generalized Linear Models
Conditionally Specified Models
Directly Specified (Marginal) Models
Semiparametric Regression
Interpreting Covariate Effects
Further Reading
Methods of Bayesian Inference
Overview
Likelihood and Posterior Distribution
Prior Distributions
Computation of the Posterior Distribution
Model Comparisons and Assessing Model Fit
Nonparametric Bayes
Further Reading
Bayesian Analysis using Data on Completers
Overview
Model Selection and Inference with a Multivariate Normal Model: Analysis of the Growth Hormone Clinical Study
Inference with a Normal Random Effects Model: Analysis of the Schizophrenia Clinical Trial
Model Selection and Inference for Binary Longitudinal Data: Analysis of CTQ I
Summary
Missing Data Mechanisms and Longitudinal Data
Introduction
Full vs. Observed Data
Full-Data Models and Missing Data Mechanisms
Assumptions about Missing Data Mechanism
Missing at Random Applied to Dropout Processes
Observed-Data Posterior of Full-Data Parameters
The Ignorability Assumption
Examples of Full-Data Models under MAR
Full-Data Models under MNAR
Summary
Further Reading
Inference about Full-Data Parameters under Ignorability
Overview
General Issues in Model Specification
Posterior Sampling Using Data Augmentation
Covariance Structures for Univariate Longitudinal Processes
Covariate-Dependent Covariance Structures
Multivariate Processes
Model Comparisons and Assessing Model Fit with Incomplete Data under Ignorability
Further Reading
Case Studies: Ignorable Missingness
Overview
Analysis of the Growth Hormone Study under MAR
Analysis of the Schizophrenia Clinical Trial under MAR Using Random Effects Models
Analysis of CTQ I Using Marginalized Transition Models under MAR
Analysis of Weekly Smoking Outcomes in CTQ II Using Auxiliary Variable MAR
Analysis of HERS CD4 Data under Ignorability Using Bayesian p-Spline Models
Summary
Models for handling Nonignorable Missingness
Overview
Extrapolation Factorization
Selection Models
Mixture Models
Shared Parameter Models
Model Comparisons and Assessing Model Fit in Nonignorable Models
Further Reading
Informative Priors and Sensitivity Analysis
Overview
Some Principles
Parameterizing the Full-Data Model
Pattern-Mixture Models
Selection Models
Elicitation of Expert Opinion, Construction of Informative Priors, and Formulation of Sensitivity Analyses
A Note on Sensitivity Analysis in Fully Parametric Models
Literature on Local Sensitivity
Further Reading
Case Studies: Model Specification and Data Analysis under Missing Not at Random
Overview
Analysis of Growth Hormone Study Using Pattern-Mixture Models
Analysis of OASIS Study Using Selection and Pattern-Mixture Models
Analysis of Pediatric AIDS Trial Using Mixture of Varying Coefficient Models
Appendix: distributions
Bibliography
Index
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Review quote

The authors combine their expertise in longitudinal data and Bayesian inference to missing data problems to give an overview of methods that can be used in various longitudinal studies. ... the examples ... are very helpful to illustrate the potential of the theory.
-Michael Bucker, Statistical Papers (2011) 52


Daniels and Hogan's is the first to explicitly focus on missing data in the context of longitudinal studies. ... I found the book extremely clear and illuminating. It is well written, with comprehensive and up-to-date references. The use of example datasets from a number of epidemiological and clinical studies illustrates how the methods and strategies being advocated can be applied in real-life settings. ... an extremely valuable resource both to applied statisticians who are faced with analyzing longitudinal data subject to missingness and methodological researchers in the area.
-Jonathan Bartlett, Statistics in Medicine, 2011, 30


... They [the authors] have gone further than anyone else in developing methods for the not missing at random (NMAR) case. ... The focus on longitudinal studies will attract many readers. ... this book is an excellent introduction and is also a first-rate treatment of cutting-edge topics. ...
-Paul D. Allison, University of Pennsylvania, Significance, September 2010


This text is the only Bayesian textbook that provides a contemporary and comprehensive treatment of Bayesian approaches to a common and critically important topic. The authors provide a scholarly treatment of Bayesian inference and supplement their treatise with concrete practical examples. The writing is clear, precise and interesting. A particularly innovative and enormously useful contribution is the authors' formalization of sensitivity analyses. They distinguish between local and global sensitivity analyses, providing the reader with examples of each. I have used the techniques proposed in the text with much success, teaching people the importance of separating what is observed from what is assumed. I strongly endorse this book.
-Sharon-Lise Normand, Harvard School of Public Health, Boston, Massachusetts, USA


...the book under review appears to be the first reference that solely focuses on Bayesian approaches to handle missing data in longitudinal studies. ... Overall I think this is a well-written technical monograph. The preliminary sections on longitudinal data analysis, Bayesian statistics, and missing data ... are well written and serve to make this book a self-contained reference. The models presented to analyze missing data in longitudinal studies cover many ideas from the current literature, and some of the methods are at the cutting edge of research. The book will probably have greatest appeal to statisticians with a research interest in missing data. Although I also think applied biostatisticians who like to use Bayesian approaches and in particular WinBUGS will find this book very useful.
-Journal of Biopharmaceutical Statistics, 2009


...a timely and thorough review of this maturing research area. ... The book is comprehensive in covering models for both continuous and discrete outcomes from both the pattern mixture and selection modeling perspectives. ... The book's composition offers much to admire. The writing is clear and direct, the notation is sensible and consistent, and tables and figures are simple and uncluttered. Typos are mercifully rare ... Biostatisticians who seek a clear and thorough overview of the state of knowledge in this area would do well to make this excellent book their first stop.
-Biometrics, March 2009
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